Proposes a method for generating prediction intervals in dose-response models using conformal prediction.
problem Uncertainty quantification in continuous treatments for personalized healthcare decisions.
method Causal dose-response problem framed as covariate shift, using weighted conformal prediction with propensity estimation and kernel functions.
result Demonstrates the significance of covariate shift assumptions for robust prediction intervals.
Paper develops methods to estimate derivative of dose-response curve for continuous treatments.
problem Estimating the derivative of the dose-response curve for continuous treatments.
method Doubly robust (DR) inference method using kernel smoothing, bias-corrected IPW and DR estimators.
result Proposes novel bias-corrected IPW and DR estimators for continuous treatments.
Proposes a method to estimate causal effects of continuous treatments using instrumental variables.
problem Estimating causal effects of continuous treatments in the presence of unmeasured confounders.
method Introduces a novel framework using instrumental variables and a uniform regular weighting function to identify and estimate average dose-response functions.
result Establishes the asymptotic properties of the proposed methods for estimating average dose-response functions.
Controlled interventions provide the most direct source of information for learning causal effects. In particular, a dose-response curve can be learned by varying the treatment level and observing the corresponding outcomes. However, interventions can be expensive and time-consuming. Observational data, where the treat…
Proposes DeepSDRF for continuous treatment recommendation from clinical survival data.
problem Continuous treatment recommendation in medical settings with survival data.
method Deep Survival Dose Response Function (DeepSDRF) for learning conditional average dose response (CADR) function.
result Similar performance of recommender algorithms based on random search and reinforcement learning.
Estimating what would be an individual's potential response to varying levels of exposure to a treatment is of high practical relevance for several important fields, such as healthcare, economics and public policy. However, existing methods for learning to estimate counterfactual outcomes from observational data are ei…
Paper introduces new estimator for continuous treatment effects.
problem Estimating the average dose-response function of continuous treatments.
method Utilizes ADML and DML tools, with a novel debiasing method.
result Proves asymptotic normality and shows good performance in simulations.
SHIFT improves robustness in estimating dose-response functions with heavy-tailed contamination.
problem Outliers bias estimates of average dose-response functions in heavy-tailed data.
method SHIFT combines cross-fit nuisance orthogonalization, Welsch-loss, and defensive OLS refit.
result SHIFT reduces RMSE from 1.03 to 0.33 on localized contamination test.
Proposes estimators for complex dose-response curves using kernel methods.
problem Estimating complex dose-response curves with continuous treatments, mediators, and covariates.
method Kernel ridge regression with sequential kernel embedding technique.
result Simple estimators for mediated and time-varying dose response curves with nonasymptotic uniform rates.
Exploratory cancer drug studies test multiple tumor cell lines against multiple candidate drugs. The goal in each paired (cell line, drug) experiment is to map out the dose-response curve of the cell line as the dose level of the drug increases. We propose Bayesian Tensor Filtering (BTF), a hierarchical Bayesian model …
Many modern data sets are sampled with error from complex high-dimensional surfaces. Methods such as tensor product splines or Gaussian processes are effective/well suited for characterizing a surface in two or three dimensions but may suffer from difficulties when representing higher dimensional surfaces. Motivated by…
ContiVAE estimates individual dose-response curves from unobserved confounders using observational data.
problem Estimating causal effects of continuous treatments considering unobserved confounders.
method Variational auto-encoder with a Tilted Gaussian prior distribution modeling hidden confounders as latent variables.
result ContiVAE outperforms existing methods by up to 62% in predicting individual dose-response curves.
Proposes a new method for estimating non-pathwise differentiable functional parameters.
problem Estimating dose-response curves for continuous exposure.
method Targeted Highly Adaptive Lasso (HAL) for non-pathwise differentiable functional parameters.
result The Targeted HAL-MLE achieves dimension-free rates up to log(n) factors and outperforms other methods in simulations.
Method bounds continuous-valued treatment effects when confounding variables are hidden.
problem Inferring causal effects of continuous treatments when hidden confounders are present.
method Novel methodology to bound average and conditional average continuous-valued treatment effects.
result Method gives tighter coverage of true dose-response curve than existing methods.
Kernel methods identify treatment effects with unobserved confounding using negative controls.
problem Learning causal relationships with unmeasured confounding.
method Kernel ridge regression algorithms for nonparametric treatment effects.
result Uniform consistency and finite sample rates of convergence proved.
Kernel method estimates long-term effects from short-term data.
problem Estimating long-term effects from short-term data in continuous actions.
method Kernel ridge regression to embed and extrapolate long-term effects.
result Uniform consistency and nonasymptotic error bounds for the estimator.
Develops a scalable model for drug combination prediction in cancer.
problem Accurate prediction of drug combinations for cancer treatment.
method Permutation invariant multi-output Gaussian Processes with variational approximation and deep generative model.
result Model efficiently borrows information across drug combinations and provides uncertainty quantification.
The literature of heavy tails (typically) starts with a random walk and finds mechanisms that lead to fat tails under aggregation. We follow the inverse route and show how starting with fat tails we get to thin-tails when deriving the probability distribution of the response to a random variable. We introduce a general…
New framework for managing medical risks using convex responses.
problem Medical risk management and dosing optimization.
method Analyzes convex and concave dose-response functions, defines antifragility.
result Proposes a mathematical framework for integrating nonlinearities in oncology.
Proposes VCNet for estimating ADRFs of continuous treatments.
problem Estimating ADRFs of continuous treatments from observational data.
method VCNet for improved model expressiveness and continuity; targeted regularization for finite sample performance.
result Improves model expressiveness and continuity of ADRFs.
A new algorithm uses concavity in Gaussian processes to optimize decisions in bandit problems.
problem Optimizing decisions in sequential problems with context-dependent rewards.
method Proposes a UCB algorithm using a shape-constrained reward function estimator based on a Gaussian Process model with concavity constraints.
result Derives regret bounds for the proposed UCB algorithm.
Proposes a new method to measure and avoid harm in machine learning decisions.
problem Measuring and avoiding harm in machine learning algorithms.
method Formal definition of harm and benefit using causal models, counterfactual objective functions.
result Demonstrates that standard machine learning methods can lead to harmful policies under distributional shifts.
Efficient estimators for smooth Hilbert-valued parameters with theoretical guarantees.
problem Estimating smooth Hilbert-valued parameters with theoretical guarantees.
method Pathwise differentiable Hilbert-valued parameters, efficient influence functions, regularized one-step estimators.
result Theoretical guarantees for efficient estimators even when nuisance functions are arbitrary.
Mixed effects (ME) models inform a vast array of problems in the physical and social sciences, and are pervasive in meta-analysis. We consider ME models where the random effects component is linear. We then develop an efficient approach for a broad problem class that allows nonlinear measurements, priors, and constrain…
Develops scalable methods to assess sensitivity and uncertainty in continuous treatment effects.
problem Estimating effects of continuous-valued interventions from observational data, especially when ignorability and positivity assumptions are violated.
method Continuous treatment-effect marginal sensitivity model (CMSM), scalable algorithm, uncertainty-aware deep models.
result Derives bounds that agree with observed data and a defined level of hidden confounding.
Kernel ridge regression for causal inference with missing data.
problem Estimating treatment effects with missing data in selected samples.
method Kernel ridge regression estimators for nonparametric dose response curves and semiparametric treatment effects.
result Uniform consistency and finite sample rates for continuous treatment, root-n consistency for discrete treatment.
GCF estimates heterogeneous treatment effects for continuous treatments in online marketplaces.
problem Estimating heterogeneous treatment effects for continuous treatments in online marketplaces.
method Kernel-based doubly robust estimator and distance-based splitting criterion.
result GCF estimates heterogeneous treatment effects for continuous treatments effectively.
The vast majority of current machine learning algorithms are designed to predict single responses or a vector of responses, yet many types of response are more naturally organized as matrices or higher-order tensor objects where characteristics are shared across modes. We present a new machine learning algorithm BaTFLE…
New method estimates extreme outcomes in heavy-tailed data, breaking circular dependence.
problem Estimating outcomes for extreme events in heavy-tailed data.
method Proposes an ADRF estimator that includes a structured tail-shape output and a diagnostic to evaluate tail shape.
result Successfully reduces MAE in deep-tail and conditional-shortfall predictions.
ALMAB-DC optimizes expensive black-box experiments using active learning and distributed computing.
problem Efficiently optimizing expensive, gradient-free objectives in computational statistics and machine learning.
method Combines active learning, multi-armed bandits, and distributed asynchronous computing.
result Achieves lower simple regret and superior performance in various tasks compared to non-ALMAB baselines.
New neural network models for complex functional data analysis.
problem Complex relations between functional predictors and responses.
method Function-on-Function regression models using neural networks with continuous hidden layers.
result Demonstrated power and flexibility in handling complex functional models.
Distance function to a finite set is a topological Morse function.
problem Characterizing the topological Morse function of a finite set.
method Analyzing the distance function to a finite set in \(\mathbb{R}^n\).
result Distance function is a topological Morse function, with precise critical points and indices.
Introduces new weighted floating functions and affine surface areas.
problem Developing new mathematical concepts for convex bodies.
method Introducing weighted floating functions and weighted functional affine surface areas.
result New relations to traditional and classical affine surface areas.
Develops methods for selecting and estimating smooth functional coefficients in high-dimensional multivariate functional data.
problem Functional predictor selection and estimation of smooth functional coefficients in high-dimensional multivariate functional data.
method Functional group-sparse regression methods in a generic Hilbert space of infinite dimension.
result Consistency of estimation and selection (oracle property) under infinite-dimensional Hilbert spaces.
Neural networks can approximate functionals on RKHS with error bounds.
problem Approximating functionals on RKHS using neural networks.
method Interpolating orthogonal projections in RKHS using point evaluations.
result Explicit error bounds for various kernels (inverse multiquadric, Gaussian, Sobolev).
FFBO optimizes functions as inputs and outputs, improving on existing BO methods.
problem Optimizing functions as both inputs and outputs in complex systems.
method Function-on-function Gaussian process (FFGP) model with a separable operator-valued kernel, scalar upper confidence bound (UCB) acquisition function, and scalable functional gradient ascent algorithm (FGA).
result FFBO outperforms existing methods in synthetic and real-world data.
Chirped sinosoids and interferometric phase plots are functions that are not periodic, but are the composition of a smooth function and a periodic function. These functions functions factor into a pair of maps: from their domain to a circle, and from a circle to their codomain. One can easily imagine replacing the circ…
The Fridman function is bounded by the injectivity radius for certain hyperbolic manifolds.
problem Bounding the Fridman function for hyperbolic manifolds.
method Analyzing the relationship between the Fridman function and the injectivity radius function.
result The Fridman function is bounded above by the injectivity radius function for certain hyperbolic manifolds.
Optimally estimates a functional using nuisance function tuning and sample splitting.
problem Estimating optimal rates for a doubly robust functional.
method Combines nuisance function tuning and sample splitting strategies.
result Shows optimal rates of convergence for various estimators.
The paper proves isoparametric functions on Finsler space forms under specific conditions.
problem Understanding isoparametric functions in Finsler space forms.
method Proving transnormal functions as isoparametric functions and constructing global and local isoparametric functions using the distance function.
result Generalization of Theorem B to Finsler space forms.
Paper introduces a nonparametric functional graphical model for random functions.
problem Estimating probabilistic conditional independence in functional graphical models.
method Functional sufficient dimension reduction to relax Gaussian or copula Gaussian assumptions.
result Enhances estimation accuracy and retains probabilistic conditional independence.
Robustifies elicitable functionals to handle small distribution misspecifications.
problem Determining uniquely optimal forecasts under distributional misspecification.
method Integrates statistical robustness into elicitable functionals using Kullback-Leibler divergence.
result Robust elicitable functionals admit unique solutions at the boundary of uncertainty regions.
The paper characterizes strong Hamel functions using symmetries and proves their preservation properties.
problem Characterizing strong Hamel functions and their symmetries in Finsler spaces.
method Analyzing geodesic spray, strong dual symmetries, and strong dynamical symmetries.
result Strong Hamel functions can be characterized in terms of strong dual symmetries and strong dynamical symmetries.
Study biharmonic functions on vector bundles with spherical symmetry.
problem Investigate biharmonic functions on vector bundles with spherically symmetric metrics.
method Analyze vertical lifts and radial functions of functions on vector bundle manifolds.
result Construct an infinite two-parameter family of proper biharmonic functions.
Two new methods improve forecasting of functional time series data.
problem Forecasting of functional time-dependent data.
method Functional Singular Spectrum Analysis (FSFA) based forecasting methods.
result Our methods outperform existing algorithms for periodic stochastic processes.
This paper introduces the concept of functional current as a mathematical framework to represent and treat functional shapes, i.e. sub-manifold supported signals. It is motivated by the growing occurrence, in medical imaging and computational anatomy, of what can be described as geometrico-functional data, that is a da…
Study stabilizers of smooth functions on surfaces, focusing on Morse-Bott functions.
problem Understanding the homotopy type of stabilizers of smooth functions on surfaces.
method Analyzing the homotopy properties of stabilizers for a specific class of smooth functions.
result The homotopy type of the connected component of the identity map of the stabilizer is completely described for Morse-Bott functions.
The paper connects convex functions to p-subharmonic functions and proves their equivalence.
problem Understanding the relationship between convex functions and p-subharmonic functions.
method Average principle, variational methods, and PDE techniques.
result Convex functions on R^n are p-subharmonic for every p > 1.