New methods for time-to-event prediction are proposed by extending the Cox proportional hazards model with neural networks. Building on methodology from nested case-control studies, we propose a loss function that scales well to large data sets, and enables fitting of both proportional and non-proportional extensions o…
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48 results for “Cox proportional regression”
Bias - variance decomposition of the expected error defined for regression and classification problems is an important tool to study and compare different algorithms, to find the best areas for their application. Here the decomposition is introduced for the survival analysis problem. In our experiments, we study bias -…
Paper compares different models for time-to-event analysis.
problem Comparing models for time-to-event analysis.
method Experimental comparison of semi-parametric, parametric, and machine learning models.
result Models' performance evaluated using concordance index.
Extends deep learning for nonlinear Cox regression variable selection.
problem Variable selection for nonlinear Cox regression model.
method Extends LassoNet to survival data for nonlinear Cox model.
result Valid and effective method demonstrated through simulations.
The Cox proportional hazards model is ubiquitous in the analysis of time-to-event data. However, when the data dimension p is comparable to the sample size , maximum likelihood estimates for its regression parameters are known to be biased or break down entirely due to overfitting. This prompted the introduction of …
Study compares Cox model and RSF for predicting patient survival, finding RSF superior in certain scenarios.
problem Comparing predictive accuracy of Cox proportional hazards model and Random Survival Forest for patient-specific survival probabilities.
method Conducted a comprehensive comparison study using simulation scenarios and real-world datasets.
result RSF outperforms Cox model in nonproportional hazards settings and with treatment-covariate interactions.
Semi-parametric survival analysis methods like the Cox Proportional Hazards (CPH) regression (Cox, 1972) are a popular approach for survival analysis. These methods involve fitting of the log-proportional hazard as a function of the covariates and are convenient as they do not require estimation of the baseline hazard …
The method integrates survival constraints into NMF for identifying survival-associated gene clusters.
problem Understanding and interpreting high-dimensional biological data for disease markers.
method Cox proportional hazards regression integrated with NMF via proportional hazards non-negative matrix factorization.
result The method can uncover survival-associated gene clusters in cancer gene expression data.
Federated Cox model handles non-proportional hazards in siloed data.
problem Handling non-proportional hazards in federated healthcare data.
method Developed a federated Cox model that relaxes proportional hazards assumption.
result Federated model performs similarly to standard models on clinical datasets.
Paper connects Plackett-Luce and Cox models for preference estimation.
problem Estimating preferences from annotated data.
method Connects Plackett-Luce model to Cox Proportional Hazards model.
result Implications of the connection between the two models.
Develops a method to estimate average hazard under non-proportional hazards without relying on proportional hazards assumption.
problem Estimation of treatment effects when hazards are non-proportional, leading to unstable hazard ratios.
method Semiparametric, doubly robust framework for covariate-adjusted average hazard estimation.
result Valid sqrt{n} inference with small bias and near-nominal confidence-interval coverage across proportional and non-proportional hazards settings.
Proposes FarmHazard model for hazard regression with correlated covariates.
problem Model selection challenges in high-dimensional data with correlated covariates.
method Factor-Augmented Regularized Model for Hazard Regression (FarmHazard) that learns latent factors and idiosyncratic components.
result Proves model selection and estimation consistency under mild conditions.
The study examines Cox models for lifetime loan default risk, addressing biased estimates by incorporating recurrent events.
problem Ignoring recurrent default events in Cox models leads to biased and inaccurate PD estimates.
method Investigates and compares different Cox models (Andersen-Gill and Prentice-Williams-Peterson) for lifetime loan default risk.
result The Andersen-Gill model underperforms compared to the Prentice-Williams-Person model and the time to first default model.
Enhances Cox model for survival analysis with symbolic non-linear log-risk functions.
problem Limited interpretability and non-linearity in traditional Cox models.
method Introduces GCPH model using Kolmogorov-Arnold Networks for symbolic non-linear log-risk functions.
result GCPH achieves competitive performance and superior interpretability.
Efficiently estimates Cox model coefficients without sharing data.
problem Privacy and ownership concerns in multi-center biomedical studies.
method Communication-efficient iterative distributed algorithms for estimation and inference.
result Achieves convergence rate of full-sample estimator with minimal iterations.
To better understand the interplay of censoring and sparsity we develop finite sample properties of nonparametric Cox proportional hazard's model. Due to high impact of sequencing data, carrying genetic information of each individual, we work with over-parametrized problem and propose general class of group penalties s…
CoxSE combines deep learning with self-explaining neural networks for survival analysis.
problem Improving predictive power of Cox Proportional Hazards model while maintaining explainability.
method Proposes CoxSE, a locally explainable Cox proportional hazards model using SENN, and CoxSENAM, a hybrid model with NAM.
result CoxSE provides more stable and consistent explanations while maintaining predictive power.
High throughput genetic sequencing arrays with thousands of measurements per sample and a great amount of related censored clinical data have increased demanding need for better measurement specific model selection. In this paper we establish strong oracle properties of nonconcave penalized methods for nonpolynomial (N…
UK hosts 62.89% of all HYIPs, many registered as 'limited company'.
problem Understanding the prevalence and characteristics of HYIPs in the UK.
method Examined HYIPs' registration in UK, analyzed social media and payment processors, used Cox proportional regression analysis.
result HYIPs with valid UK addresses tend to have longer lifespans.
New optimization methods improve Cox Proportional Hazards model training for high-dimensional data.
problem Vanishing second order derivatives in Newton method prevent convergence for high-dimensional CPH model training.
method Construct and minimize surrogate functions exploiting hidden mathematical structures of CPH model.
result Global convergence and monotonic loss decrease, leading to sparse and high-quality models.
A new model avoids the PH assumption for right-censored survival data.
problem Inflexibility of Cox model when PH assumption fails.
method Deep partially linear transformation model (DPLTM) for right-censored data.
result The DPLTM avoids the curse of dimensionality and retains interpretability.
Active-set algorithm improves Cox regression for shape-restricted covariates.
problem Improving Cox regression for shape-restricted covariates.
method Shape-restricted inference using active-set optimization for spline basis expansion.
result Active-set algorithm produces accurate linear covariate effect estimates.
Study compares LSTM, Transformer, and Mamba for bladder cancer recurrence analysis.
problem Complex time-dependent data in bladder cancer recurrence analysis.
method Evaluation of LSTM, Transformer, and Mamba models using Cox proportional hazards model.
result LSTM-Cox model outperforms Transformer-Cox and Mamba-Cox models in prediction accuracy.
New method estimates survival risks without strong proportional hazard assumptions.
problem Time-to-event prediction with censored data and competing risks.
method Jointly learns deep nonlinear representations for fully parametric survival regression.
result Demonstrates benefits in real-world datasets with different censoring levels.
Improved survival analysis using square root Cox's models and neural networks.
problem Feature selection in survival analysis.
method Square root Cox's survival analysis by the fittest linear and neural networks model, directly tuning penalty parameter λ.
result Substantially improved over traditional methods, achieving phase transition in feature selection.
This work improves confidence intervals for Cox model test error using nested CV.
problem Insufficient understanding of confidence intervals for cross-validation in Cox model.
method Generalized nested cross-validation to Cox proportional hazards model.
result Improved coverage of confidence intervals for Cox model test error.
Paper addresses data heterogeneity in federated learning for CoxPH models in healthcare.
problem Data heterogeneity in federated learning of CoxPH models for healthcare.
method Feature-based clustering and event-based reporting strategy.
result Enhanced model accuracy and performance in federated survival analysis.
Kernel Cox partially linear regression: building predictive models for cancer patients' survivalstat.ML
Paper develops a method to predict cancer patient survival using molecular profiles.
problem Accurately predicting cancer patient survival with complex survival-molecular profile relationships.
method Kernel Cox partially linear regression with a novel regularized garrotized kernel machine (RegGKM) method.
result The proposed method outperforms other methods in predicting survival accuracy.
Proposes isotonic regression for calibrating Deep Cox models' survival probabilities.
problem Poor calibration of Deep Cox models' survival probabilities.
method Isotonic regression for post hoc calibration of Deep Cox models.
result Establishes favorable theoretical guarantees and demonstrates empirical effectiveness.
In this paper we utilize a survival analysis methodology incorporating Bayesian additive regression trees to account for nonlinear and additive covariate effects. We compare the performance of Bayesian additive regression trees, Cox proportional hazards and random survival forests models for censored survival data, usi…
Adapts bandit algorithms for online survival analysis under Cox PH model.
problem Online survival analysis challenges in a bandit framework.
method Adapts three bandit algorithms to balance exploration and exploitation.
result Demonstrates sublinear regret bounds and effective learning of treatment policies.
SurvLIME explains survival models by approximating them with Cox models.
problem Explaining complex survival models in machine learning.
method Applies Cox proportional hazards model to approximate survival model locally.
result Demonstrates efficiency through numerical experiments.
Survival analysis/time-to-event models are extremely useful as they can help companies predict when a customer will buy a product, churn or default on a loan, and therefore help them improve their ROI. In this paper, we introduce a new method to calculate survival functions using the Multi-Task Logistic Regression (MTL…
Variable selection in high dimensional space has challenged many contemporary statistical problems from many frontiers of scientific disciplines. Recent technology advance has made it possible to collect a huge amount of covariate information such as microarray, proteomic and SNP data via bioimaging technology while ob…
New deep Cox mixture model improves survival analysis performance.
problem Challenges in survival analysis due to censoring and healthcare applications.
method Learning mixtures of Cox regressions with deep neural networks for hazard ratios and non-parametric baseline hazard.
result Our approach outperforms classical and modern survival analysis methods, especially in minority demographics.
An accurate model of patient-specific kidney graft survival distributions can help to improve shared-decision making in the treatment and care of patients. In this paper, we propose a deep learning method that directly models the survival function instead of estimating the hazard function to predict survival times for …
MEC-Cox: A Machine-Learning-Assisted Generalized Entropy Calibration Method for Estimating ATT Marginal Hazard-Ratio
problem Estimating ATT marginal hazard-ratio in externally controlled survival trials
method Machine-learning-assisted generalized entropy calibration for IPW Cox regression
result Reduces bias, increases efficiency, and improves coverage
We consider the finite sample properties of the regularized high-dimensional Cox regression via lasso. Existing literature focuses on linear models or generalized linear models with Lipschitz loss functions, where the empirical risk functions are the summations of independent and identically distributed (iid) losses. T…
Enhances survival analysis predictions with a robust learning approach.
problem Improving robustness and accuracy in survival analysis predictions.
method Integrates Distributionally Robust Learning (DRL) into Cox regression using Wasserstein distance-based ambiguity set.
result Demonstrates superior performance in prediction accuracy and robustness compared to traditional methods.
A new method for federated survival analysis using Cox models.
problem Non-separability of Cox PH model loss function in federated learning.
method Discrete-time Cox model, separable loss function, federated learning.
result Improved performance and communication efficiency compared to previous methods.
Flexible Deep Neural Networks for Partially Linear Survival Data: Estimation and Survival Inferencestat.ML
Flexible DNN for survival data, avoiding proportional hazards assumption.
problem Survival analysis with complex interactions and non-proportional hazards.
method Partially linear DNN model with a flexible nonparametric component.
result FLEXI-Haz achieves optimal convergence rates and asymptotic efficiency.
New statistical properties for mini-batch Cox-NN optimization.
problem Optimizing deep Cox neural networks using mini-batches.
method Developed mini-batch maximum partial-likelihood estimator (mb-MPLE) for Cox-NN.
result mb-MPLE is consistent and achieves optimal convergence rate.
FastCPH efficiently predicts survival times using neural networks.
problem Improving efficiency and accuracy of Cox proportional hazards models in neural networks.
method Developed FastCPH, a linear-time method supporting Breslow and Efron methods for tied events.
result Outperforms existing CoxPH approaches and selects useful covariates.
Medical practitioners use survival models to explore and understand the relationships between patients' covariates (e.g. clinical and genetic features) and the effectiveness of various treatment options. Standard survival models like the linear Cox proportional hazards model require extensive feature engineering or pri…
Study uses machine learning and survival analysis to predict CKD progression.
problem Early detection and management of CKD to reduce ESRD risk.
method Combines machine learning and classical statistical models to identify novel CKD progression predictors.
result Deep learning models outperform other methods in predicting CKD progression.
Paper extends multi-task Gaussian Cox processes for heterogeneous tasks.
problem Modeling multiple heterogeneous correlated tasks jointly.
method Data augmentation and mean-field approximation for non-conjugate Bayesian inference.
result Demonstrates improved performance and inference on synthetic and real data.
An accurate model of a patient's individual survival distribution can help determine the appropriate treatment for terminal patients. Unfortunately, risk scores (e.g., from Cox Proportional Hazard models) do not provide survival probabilities, single-time probability models (e.g., the Gail model, predicting 5 year prob…
SurvLIMEpy is a Python package for computing feature importance in survival analysis.
problem Computing feature importance in survival analysis models.
method Parallelized implementation of the SurvLIME algorithm for various survival models.
result SurvLIMEpy accurately captures feature importance in survival analysis models.