Federated Cox model handles non-proportional hazards in siloed data.
problem Handling non-proportional hazards in federated healthcare data.
method Developed a federated Cox model that relaxes proportional hazards assumption.
result Federated model performs similarly to standard models on clinical datasets.
Paper connects Plackett-Luce and Cox models for preference estimation.
problem Estimating preferences from annotated data.
method Connects Plackett-Luce model to Cox Proportional Hazards model.
result Implications of the connection between the two models.
Develops a method to estimate average hazard under non-proportional hazards without relying on proportional hazards assumption.
problem Estimation of treatment effects when hazards are non-proportional, leading to unstable hazard ratios.
method Semiparametric, doubly robust framework for covariate-adjusted average hazard estimation.
result Valid sqrt{n} inference with small bias and near-nominal confidence-interval coverage across proportional and non-proportional hazards settings.
Study compares Cox model and RSF for predicting patient survival, finding RSF superior in certain scenarios.
problem Comparing predictive accuracy of Cox proportional hazards model and Random Survival Forest for patient-specific survival probabilities.
method Conducted a comprehensive comparison study using simulation scenarios and real-world datasets.
result RSF outperforms Cox model in nonproportional hazards settings and with treatment-covariate interactions.
CoxSE combines deep learning with self-explaining neural networks for survival analysis.
problem Improving predictive power of Cox Proportional Hazards model while maintaining explainability.
method Proposes CoxSE, a locally explainable Cox proportional hazards model using SENN, and CoxSENAM, a hybrid model with NAM.
result CoxSE provides more stable and consistent explanations while maintaining predictive power.
Semi-parametric survival analysis methods like the Cox Proportional Hazards (CPH) regression (Cox, 1972) are a popular approach for survival analysis. These methods involve fitting of the log-proportional hazard as a function of the covariates and are convenient as they do not require estimation of the baseline hazard …
Paper compares different models for time-to-event analysis.
problem Comparing models for time-to-event analysis.
method Experimental comparison of semi-parametric, parametric, and machine learning models.
result Models' performance evaluated using concordance index.
New optimization methods improve Cox Proportional Hazards model training for high-dimensional data.
problem Vanishing second order derivatives in Newton method prevent convergence for high-dimensional CPH model training.
method Construct and minimize surrogate functions exploiting hidden mathematical structures of CPH model.
result Global convergence and monotonic loss decrease, leading to sparse and high-quality models.
Enhances Cox model for survival analysis with symbolic non-linear log-risk functions.
problem Limited interpretability and non-linearity in traditional Cox models.
method Introduces GCPH model using Kolmogorov-Arnold Networks for symbolic non-linear log-risk functions.
result GCPH achieves competitive performance and superior interpretability.
To better understand the interplay of censoring and sparsity we develop finite sample properties of nonparametric Cox proportional hazard's model. Due to high impact of sequencing data, carrying genetic information of each individual, we work with over-parametrized problem and propose general class of group penalties s…
The method integrates survival constraints into NMF for identifying survival-associated gene clusters.
problem Understanding and interpreting high-dimensional biological data for disease markers.
method Cox proportional hazards regression integrated with NMF via proportional hazards non-negative matrix factorization.
result The method can uncover survival-associated gene clusters in cancer gene expression data.
Paper addresses data heterogeneity in federated learning for CoxPH models in healthcare.
problem Data heterogeneity in federated learning of CoxPH models for healthcare.
method Feature-based clustering and event-based reporting strategy.
result Enhanced model accuracy and performance in federated survival analysis.
New methods for time-to-event prediction are proposed by extending the Cox proportional hazards model with neural networks. Building on methodology from nested case-control studies, we propose a loss function that scales well to large data sets, and enables fitting of both proportional and non-proportional extensions o…
An accurate model of patient-specific kidney graft survival distributions can help to improve shared-decision making in the treatment and care of patients. In this paper, we propose a deep learning method that directly models the survival function instead of estimating the hazard function to predict survival times for …
This work improves confidence intervals for Cox model test error using nested CV.
problem Insufficient understanding of confidence intervals for cross-validation in Cox model.
method Generalized nested cross-validation to Cox proportional hazards model.
result Improved coverage of confidence intervals for Cox model test error.
Variable selection in high dimensional space has challenged many contemporary statistical problems from many frontiers of scientific disciplines. Recent technology advance has made it possible to collect a huge amount of covariate information such as microarray, proteomic and SNP data via bioimaging technology while ob…
SurvLIME explains survival models by approximating them with Cox models.
problem Explaining complex survival models in machine learning.
method Applies Cox proportional hazards model to approximate survival model locally.
result Demonstrates efficiency through numerical experiments.
Adapts bandit algorithms for online survival analysis under Cox PH model.
problem Online survival analysis challenges in a bandit framework.
method Adapts three bandit algorithms to balance exploration and exploitation.
result Demonstrates sublinear regret bounds and effective learning of treatment policies.
Proposes FarmHazard model for hazard regression with correlated covariates.
problem Model selection challenges in high-dimensional data with correlated covariates.
method Factor-Augmented Regularized Model for Hazard Regression (FarmHazard) that learns latent factors and idiosyncratic components.
result Proves model selection and estimation consistency under mild conditions.
Extends deep learning for nonlinear Cox regression variable selection.
problem Variable selection for nonlinear Cox regression model.
method Extends LassoNet to survival data for nonlinear Cox model.
result Valid and effective method demonstrated through simulations.
Study compares LSTM, Transformer, and Mamba for bladder cancer recurrence analysis.
problem Complex time-dependent data in bladder cancer recurrence analysis.
method Evaluation of LSTM, Transformer, and Mamba models using Cox proportional hazards model.
result LSTM-Cox model outperforms Transformer-Cox and Mamba-Cox models in prediction accuracy.
High throughput genetic sequencing arrays with thousands of measurements per sample and a great amount of related censored clinical data have increased demanding need for better measurement specific model selection. In this paper we establish strong oracle properties of nonconcave penalized methods for nonpolynomial (N…
Flexible DNN for survival data, avoiding proportional hazards assumption.
problem Survival analysis with complex interactions and non-proportional hazards.
method Partially linear DNN model with a flexible nonparametric component.
result FLEXI-Haz achieves optimal convergence rates and asymptotic efficiency.
Bias - variance decomposition of the expected error defined for regression and classification problems is an important tool to study and compare different algorithms, to find the best areas for their application. Here the decomposition is introduced for the survival analysis problem. In our experiments, we study bias -…
SurvLIME-KS improves survival model explanations robustly.
problem Improving explanations of unreliable survival models.
method SurvLIME-KS combines Cox proportional hazards model and Kolmogorov-Smirnov bounds for robust optimization.
result SurvLIME-KS minimizes average distance and maximizes distance in approximating cumulative hazard functions.
New method estimates survival risks without strong proportional hazard assumptions.
problem Time-to-event prediction with censored data and competing risks.
method Jointly learns deep nonlinear representations for fully parametric survival regression.
result Demonstrates benefits in real-world datasets with different censoring levels.
Medical practitioners use survival models to explore and understand the relationships between patients' covariates (e.g. clinical and genetic features) and the effectiveness of various treatment options. Standard survival models like the linear Cox proportional hazards model require extensive feature engineering or pri…
Study uses machine learning and survival analysis to predict CKD progression.
problem Early detection and management of CKD to reduce ESRD risk.
method Combines machine learning and classical statistical models to identify novel CKD progression predictors.
result Deep learning models outperform other methods in predicting CKD progression.
Study explains mortgage burnout using Cox hazard models.
problem Understanding burnout in mortgage pools.
method Modeling mortgage prepayment using Cox hazard processes.
result Observed pool hazard is a survival-weighted mean of individual hazards with a selection term.
Improved survival analysis using square root Cox's models and neural networks.
problem Feature selection in survival analysis.
method Square root Cox's survival analysis by the fittest linear and neural networks model, directly tuning penalty parameter λ.
result Substantially improved over traditional methods, achieving phase transition in feature selection.
SurvLIME-Inf simplifies explanation of survival models using a linear programming approach.
problem Explain complex survival models using simple linear programming.
method Uses L∞-norm for feature importance and explains black-box models. result SurvLIME-Inf outperforms SurvLIME in small training set scenarios.
Efficiently estimates Cox model coefficients without sharing data.
problem Privacy and ownership concerns in multi-center biomedical studies.
method Communication-efficient iterative distributed algorithms for estimation and inference.
result Achieves convergence rate of full-sample estimator with minimal iterations.
SurvLIMEpy is a Python package for computing feature importance in survival analysis.
problem Computing feature importance in survival analysis models.
method Parallelized implementation of the SurvLIME algorithm for various survival models.
result SurvLIMEpy accurately captures feature importance in survival analysis models.
Study uses ML to predict HL survival, outperforming CoxPH.
problem Improving survival prediction for HL patients.
method Compared multiple ML algorithms to CoxPH model.
result ML models outperform CoxPH in predicting HL survival.
A new model avoids the PH assumption for right-censored survival data.
problem Inflexibility of Cox model when PH assumption fails.
method Deep partially linear transformation model (DPLTM) for right-censored data.
result The DPLTM avoids the curse of dimensionality and retains interpretability.
We introduce a semi-parametric Bayesian model for survival analysis. The model is centred on a parametric baseline hazard, and uses a Gaussian process to model variations away from it nonparametrically, as well as dependence on covariates. As opposed to many other methods in survival analysis, our framework does not im…
The Cox proportional hazards model is ubiquitous in the analysis of time-to-event data. However, when the data dimension p is comparable to the sample size N, maximum likelihood estimates for its regression parameters are known to be biased or break down entirely due to overfitting. This prompted the introduction of …
Paper develops a method to predict cancer patient survival using molecular profiles.
problem Accurately predicting cancer patient survival with complex survival-molecular profile relationships.
method Kernel Cox partially linear regression with a novel regularized garrotized kernel machine (RegGKM) method.
result The proposed method outperforms other methods in predicting survival accuracy.
FastCPH efficiently predicts survival times using neural networks.
problem Improving efficiency and accuracy of Cox proportional hazards models in neural networks.
method Developed FastCPH, a linear-time method supporting Breslow and Efron methods for tied events.
result Outperforms existing CoxPH approaches and selects useful covariates.
Study benchmarks 19 survival models on 34 datasets, finding Cox model still best.
problem Quantitative comparison of survival models on low-dimensional data.
method Comprehensive benchmarking of 19 models on 34 datasets, tuning and evaluating using 6 metrics.
result Cox Proportional Hazards model remains best overall for low-dimensional, right-censored data.
Deep learning improves CVD risk prediction from health records.
problem Predicting cardiovascular disease risk from administrative health data.
method Combined survival analysis and deep learning models.
result Deep learning models outperform traditional Cox models in accuracy and explained time-to-event occurrence.
Proposes a flexible neural model for multi-state survival analysis.
problem Limited applicability of Cox models for multi-state and competing events.
method Uses neural ordinary differential equations to solve Kolmogorov forward equations.
result Demonstrates state-of-the-art performance and interpretability.
MEC-Cox: A Machine-Learning-Assisted Generalized Entropy Calibration Method for Estimating ATT Marginal Hazard-Ratio
problem Estimating ATT marginal hazard-ratio in externally controlled survival trials
method Machine-learning-assisted generalized entropy calibration for IPW Cox regression
result Reduces bias, increases efficiency, and improves coverage
Develops asymptotic theory for deep Cox models to enable valid inference.
problem Theoretical gaps in deep neural network estimators for Cox models.
method Asymptotic distribution theory linking in-sample optimization error to population risk.
result Pointwise and multivariate asymptotic normality for subsampled ensemble estimators.
A new method for federated survival analysis using Cox models.
problem Non-separability of Cox PH model loss function in federated learning.
method Discrete-time Cox model, separable loss function, federated learning.
result Improved performance and communication efficiency compared to previous methods.
Interpretable survival analysis improves heart failure risk prediction.
problem Improving heart failure risk prediction using survival analysis.
method Survival stacking, ControlBurn, Explainable Boosting Machines.
result Achieves state-of-the-art performance and provides novel insights.
The study examines Cox models for lifetime loan default risk, addressing biased estimates by incorporating recurrent events.
problem Ignoring recurrent default events in Cox models leads to biased and inaccurate PD estimates.
method Investigates and compares different Cox models (Andersen-Gill and Prentice-Williams-Peterson) for lifetime loan default risk.
result The Andersen-Gill model underperforms compared to the Prentice-Williams-Person model and the time to first default model.
Survival analysis of 832,941 Solana token launches shows a significant decline in graduation rate.
problem Analyzing the survival rate of Solana token launches and identifying factors affecting graduation.
method Survival analysis using Kaplan-Meier and Cox proportional-hazards models.
result The survival rate of Solana token launches has declined significantly, with a 3.18x decrease from previous rates.