The paper predicts diseases using both clinical and genomics data.
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Clinical notes contain a large amount of clinically valuable information that is ignored in many clinical decision support systems due to the difficulty that comes with mining that information. Recent work has found success leveraging deep learning models for the prediction of clinical outcomes using clinical notes. Ho…
Clinical outcome prediction based on the Electronic Health Record (EHR) plays a crucial role in improving the quality of healthcare. Conventional deep sequential models fail to capture the rich temporal patterns encoded in the longand irregular clinical event sequences. We make the observation that clinical events at a…
Novel metrics improve machine learning models for ICU patient care.
In this chapter, we provide a brief overview of applying machine learning techniques for clinical prediction tasks. We begin with a quick introduction to the concepts of machine learning and outline some of the most common machine learning algorithms. Next, we demonstrate how to apply the algorithms with appropriate to…
New method stabilizes deep learning models for clinical risk prediction.
Late fusion of clinical notes and physiological data improves ICU mortality prediction.
Predictive models identify patients at risk of severe COVID-19.
Study improves healthcare time series imputation by considering structured missingness.
Enhances clinical trial predictions by quantifying uncertainty.
SARD improves deep learning clinical prediction performance.
AI predicts medical specialty diagnostic choices from EHR records.
Unified model combines neural networks and dictionary learning for clinical predictions from brain data.
Heart failure hospitalization is a severe burden on healthcare. How to predict and therefore prevent readmission has been a significant challenge in outcomes research. To address this, we propose a deep learning approach to predict readmission from clinical notes. Unlike conventional methods that use structured data fo…
Visual system compares and evaluates machine learning models for clinical data predictions.
Clinical notes are a rich source of information about patient state. However, using them to predict clinical events with machine learning models is challenging. They are very high dimensional, sparse and have complex structure. Furthermore, training data is often scarce because it is expensive to obtain reliable labels…
Sepsis is a life-threatening condition that seriously endangers millions of people over the world. Hopefully, with the widespread availability of electronic health records (EHR), predictive models that can effectively deal with clinical sequential data increase the possibility to predict sepsis and take early preventiv…
In healthcare, patient risk stratification models are often learned using time-series data extracted from electronic health records. When extracting data for a clinical prediction task, several formulations exist, depending on how one chooses the time of prediction and the prediction horizon. In this paper, we show how…
Study improves mortality prediction in hospital patients using comprehensive feature engineering.
CoI framework models clinical feature interactions, revealing temporal dependencies and enhancing transparency.
Machine learning predicts patient recruitment for clinical trials.
Neural model predicts survival outcomes and reveals feature relationships.
Study examines impact of fairness penalties on clinical risk prediction models.
A new method uses asymmetric Shapley values to assess gene importance in clinical prediction models.
Healthcare data continues to flourish yet a relatively small portion, mostly structured, is being utilized effectively for predicting clinical outcomes. The rich subjective information available in unstructured clinical notes can possibly facilitate higher discrimination but tends to be under-utilized in mortality pred…
Acute kidney injury (AKI) in critically ill patients is associated with significant morbidity and mortality. Development of novel methods to identify patients with AKI earlier will allow for testing of novel strategies to prevent or reduce the complications of AKI. We developed data-driven prediction models to estimate…
Current clinical practice to monitor patients' health follows either regular or heuristic-based lab test (e.g. blood test) scheduling. Such practice not only gives rise to redundant measurements accruing cost, but may even lead to unnecessary patient discomfort. From the computational perspective, heuristic-based test …
New diagnostics detect variability in individual risk estimates from machine learning models in healthcare.
Method predicts biomarker trajectories with uncertainty bands for Alzheimer's disease.
Stability in clinical prediction models is crucial for transferability between studies, yet has received little attention. The problem is paramount in high dimensional data which invites sparse models with feature selection capability. We introduce an effective method to stabilize sparse Cox model of time-to-events usi…
Deep learning-based health status representation learning and clinical prediction have raised much research interest in recent years. Existing models have shown superior performance, but there are still several major issues that have not been fully taken into consideration. First, the historical variation pattern of th…
Study predicts antimicrobial resistance in ICU patients quickly.
Objectives: Electronic health records (EHRs) are only a first step in capturing and utilizing health-related data - the challenge is turning that data into useful information. Furthermore, EHRs are increasingly likely to include data relating to patient outcomes, functionality such as clinical decision support, and gen…
Novel model improves clinical risk prediction by transferring knowledge between tasks over time.
Study evaluates how framing affects machine learning models for sepsis prediction.
The paper proposes a method to predict the performance of data-driven algorithms using surrogate models.
We developed an explainable artificial intelligence (AI) early warning score (xAI-EWS) system for early detection of acute critical illness. While maintaining a high predictive performance, our system explains to the clinician on which relevant electronic health records (EHRs) data the prediction is grounded. Acute cri…
Widespread adoption of electronic health records (EHRs) has fueled the development of using machine learning to build prediction models for various clinical outcomes. This process is often constrained by having a relatively small number of patient records for training the model. We demonstrate that using patient repres…
Framework integrates brain connectivity data for clinical predictions.
Framework predicts clinical severity from rs-fMRI data using network optimization.
Review of methods enabling causal predictions under hypothetical interventions.
The availability of a large amount of electronic health records (EHR) provides huge opportunities to improve health care service by mining these data. One important application is clinical endpoint prediction, which aims to predict whether a disease, a symptom or an abnormal lab test will happen in the future according…
Clinical forecasting based on electronic medical records (EMR) can uncover the temporal correlations between patients' conditions and outcomes from sequences of longitudinal clinical measurements. In this work, we propose an intervention-augmented deep state space generative model to capture the interactions among clin…
Extends nonlinear filtering to predictable jump times.
pmsims R package uses Gaussian process for flexible sample size estimation in clinical models.
Causal ML predicts treatment outcomes, aiding personalized medicine.
Paper proposes machine learning model for early Alzheimer's diagnosis.
In this work, we consider the problem of predicting the course of a progressive disease, such as cancer or Alzheimer's. Progressive diseases often start with mild symptoms that might precede a diagnosis, and each patient follows their own trajectory. Patient trajectories exhibit wild variability, which can be associate…