Model predicts patient trajectories and interventions from EMR data.
problem Forecasting patient outcomes from EMR data.
method Deep state space generative model capturing latent state dynamics.
result Model outperforms state-of-the-art methods on real EMR data.
Deep RL optimizes lab test scheduling for better patient outcomes and cost savings.
problem Redundant lab tests lead to cost and patient discomfort.
method Deep reinforcement learning for optimal scheduling.
result Deep RL policy outperforms heuristic scheduling in both accuracy and cost.
New method forecasts values and timing in irregular time series.
problem Forecasting values and timing in sparse, irregularly sampled multivariate time series.
method Proposes a novel approach for forecasting values and timing in irregular time series.
result Successfully forecasts values and timing in irregular time series.
Unsupervised learning improves clinical predictions from medical time series.
problem Improving clinical decision making through unlabeled medical data.
method Evaluation of unsupervised representation learning on medical time series using sequence-to-sequence models.
result A forecasting Seq2Seq model with an attention mechanism achieves the best performance.
Paper presents forecasting models for platelet demand.
problem Managing platelet demand and supply is challenging due to variability and short shelf life.
method Utilized ARIMA, Prophet, lasso regression, and LSTM networks on a clinical dataset.
result Multivariate approaches generally have higher accuracy, but simpler ARIMA can suffice with sufficient data.
In many forecasting applications, it is valuable to predict not only the value of a signal at a certain time point in the future, but also the values leading up to that point. This is especially true in clinical applications, where the future state of the patient can be less important than the patient's overall traject…
Aims to integrate AI and modelling for patient health forecasting.
problem Personalized, precise treatment plans for patients.
method Graph neural network (GNNs) and generative adversarial network (GANs) for probabilistic simulations.
result Demonstrated integration of molecular data for predicting physiological state evolution.
BrainCast predicts whole-brain fMRI time series from short scans.
problem Short scans reduce fMRI data quality and statistical power.
method Spatio-temporal forecasting framework for fMRI time series.
result BrainCast improves fMRI time series quality and prediction.
Analyzes COVID-19 data to predict mortality, forecast spread, and optimize resource allocation.
problem Challenges in patient triage, treatment, and care management during the pandemic.
method Integrated four-step approach combining descriptive, predictive, and prescriptive analytics.
result Optimized resource allocation and informed policy decisions.
CASCADE improves uncertainty communication in Parkinson's disease medication management.
problem Uncertainty in clinical decision-making for Parkinson's disease patients.
method CASCADE uses a novel conformal prediction framework to adaptively scale prediction intervals based on classification uncertainty.
result CASCADE produces more efficient and robust prediction intervals for Parkinson's disease patients.
Health care is one of the most exciting frontiers in data mining and machine learning. Successful adoption of electronic health records (EHRs) created an explosion in digital clinical data available for analysis, but progress in machine learning for healthcare research has been difficult to measure because of the absen…
Most approaches to machine learning from electronic health data can only predict a single endpoint. Here, we present an alternative that uses unsupervised deep learning to simulate detailed patient trajectories. We use data comprising 18-month trajectories of 44 clinical variables from 1908 patients with Mild Cognitive…
Deep learning models interpret patient outcomes better with time aggregation.
problem Chronic ambulatory care data challenges for deep learning models.
method Time-distributed-dense layers combined with GRUs for generalization, clinical interpretation framework.
result Time-distributed-dense layers with GRUs produce the most generalizable models.
New model predicts blood glucose in diabetics with improved accuracy.
problem Forecasting blood glucose in type 1 diabetics with high accuracy.
method Integrates machine learning with existing biomedical model to capture time-varying dynamics.
result Improved long-term forecasting of blood glucose up to 6 hours.
Predicts stock price changes based on clinical trial announcements.
problem Forecasting the impact of clinical trial results on pharma stock prices.
method BERT for sentiment analysis, Temporal Fusion Transformer for forecasting, graph convolution network for event relationships, gradient boosting for price change prediction.
result Identifies two crucial factors: drug portfolio size and network effect of related events.
Framework improves clinical timeline reconstruction from text and tables.
problem Temporal precision and event timing in clinical narratives and EHRs.
method Retrieval-augmented multimodal alignment framework.
result Consistently improves absolute timestamp accuracy and temporal concordance.
Unsupervised learning summarizes EHR data into a patient status vector.
problem Challenges in modeling electronic health records due to irregularities and varying procedures/diagnoses.
method Two-step unsupervised representation learning scheme using auto-encoders and forecasting tasks.
result Improved generalization performance on mortality and readmission tasks.
Clinical notes improve ICU patient condition prediction.
problem Predicting ICU patient outcomes and resource planning.
method Joint modeling of time series data and clinical notes.
result Significant improvement in mortality prediction, decompensation modeling, and length of stay forecasting.
Crowdsourced reinforcement learning optimizes knee replacement pathway, reducing costs.
problem Optimizing the sequential decision process for knee replacement surgery.
method Reinforcement learning, value iteration, state compression, kernel representation, cross validation.
result Optimized policy reduces overall cost by 7% and excessive cost premium by 33%.
RAIM models ICU patient data for better clinical decision support.
problem Challenges in analyzing high-density, heterogeneous patient monitoring data.
method RAIM integrates continuous monitoring data and discrete clinical events using an attention mechanism.
result RAIM predicts physiological decompensation and length of stay with high accuracy.
Study forecasts aortic pressure with deep learning models.
problem Forecasting noisy, non-stationary aortic pressure.
method Used deep learning models, specifically recurrent neural networks with Legendre Memory Unit, on 25 Hz time series data.
result Recurrent neural networks with Legendre Memory Unit achieved the best performance with an overall forecasting error of 1.8 mmHg.
Project predicts Alzheimer's progression using neural networks and novel data processing.
problem Difficulty in early identification of Alzheimer's patients.
method Used machine learning, specifically neural networks, and a novel pre-processing technique.
result Neural network model accurately predicts AD progression with high accuracy.
Transformers improve Alzheimer's disease progression prediction by accounting for irregular biomarker histories.
problem Difficult prediction of medium-horizon Alzheimer's disease progression due to tied clinical scores and irregular biomarker observations.
method Developed a residual gap-aware transformer that combines statistical reference with transformer-based residual learning.
result The proposed model reduces mean error and improves prediction-observation correlation compared to baseline models.
Personalized model improves ADAS-Cog13 cognitive score forecasting.
problem Improving accuracy in predicting cognitive changes in Alzheimer's Disease.
method Meta-Weighted Gaussian Process Experts (pGPE) model for personalized forecasting.
result Meta-weighting of expert models leads to significant improvements in forecasting accuracy.
Self-supervised learning improves ECG classification performance.
problem Label scarcity in clinical 12-lead ECG data.
method Adapted self-supervised methods to ECG domain, focusing on contrastive representations and latent forecasting.
result Contrastive predictive coding adaptation yields linear evaluation performance only 0.5% below supervised performance.
RETAIN model improves glucose forecasting for diabetics, offering both accuracy and interpretability.
problem Inability of deep learning models to interpret their predictions in healthcare.
method Two-level attention mechanism in a recurrent neural network (RETAIN) architecture.
result RETAIN model achieves comparable accuracy to LSTM and FCN models while being highly interpretable.
Framework for joint learning of tasks on dementia data with missing values.
problem Lack of multi-task learning, handling time-dependent data, and missing values in dementia forecasting.
method Proposes SSHIBA model using Bayesian variational inference for imputation and combined information from different views.
result SSHIBA model outperforms baselines in predicting diagnosis, ventricle volume, and clinical scores in dementia.
We use a deep learning model trained only on a patient's blood oxygenation data (measurable with an inexpensive fingertip sensor) to predict impending hypoxemia (low blood oxygen) more accurately than trained anesthesiologists with access to all the data recorded in a modern operating room. We also provide a simple way…
Study develops a predictive model to reduce hospital readmissions.
problem Inaccurate readmission risk prediction models in clinical settings.
method Used Genetic Algorithm and Greedy Ensemble to optimize a readmission risk prediction model.
result Developed a useful risk prediction model for reducing unplanned readmissions.
HMRNN combines HMMs and neural networks for Alzheimer's disease forecasting.
problem Improving disease progression modeling with hidden states not fully known.
method Developed HMRNN combining HMMs and recurrent neural networks.
result HMRNN improves disease forecasting and offers novel clinical interpretation.
Neural SDEs model suicide risk with compact state space constraints.
problem Modeling suicide risk with irregular, noisy, and partially observed data.
method Developed neural SDEs confined to compact state spaces, addressing domain constraints and numerical stability.
result Improved forecasts and optimization dynamics over standard models on EMA datasets.
In this paper, we introduce the use of a personalized Gaussian Process model (pGP) to predict the key metrics of Alzheimer's Disease progression (MMSE, ADAS-Cog13, CDRSB and CS) based on each patient's previous visits. We start by learning a population-level model using multi-modal data from previously seen patients us…
The paper predicts diseases using both clinical and genomics data.
problem Clinical predictions using genomics data are not common.
method Integrated clinical and genomics datasets, machine learning, Principal Component Analysis for feature selection.
result 73% accuracy in predicting 75 disease classes.
Critiques binary classification evaluation methods, advocating for proper scoring rules.
problem The dominance of top-K metrics and fixed-threshold evaluations in machine learning.
method Introduces a decision-theoretic framework mapping evaluation metrics to their use cases, and implements a clipped Brier score variant.
result Demonstrates the clinical utility of proper scoring rules through a Python package, exttt{briertools}.
Improved model predicts ICU readmission and mortality with interpretable results.
problem Lack of clinically interpretable predictions from deep learning models on clinical notes.
method Augmented a convolutional model with an attention mechanism for clinical note prediction.
result Attention mechanism improves prediction performance while providing interpretable results.
New method corrects ML for informative sampling in time-series treatment outcomes.
problem Informative sampling in irregularly observed data hinders accurate treatment outcome forecasting.
method Formalized as covariate shift, proposed inverse intensity-weighting framework, TESAR-CDE.
result TESAR-CDE effectively learns treatment outcomes under informative sampling.
PASS model predicts disease progression with both accuracy and interpretability.
problem Balancing accurate disease prediction with clinically interpretable models.
method Phased LSTM units with attention mechanism for non-stationary state dynamics.
result PASS model achieves superior predictive accuracy and interpretable representations.
SparseVM registers clinical 3D scans faster and more accurately.
problem Inaccurate and slow registration of sparse clinical 3D scans.
method Learning-based registration method tailored for clinical sparse MRI.
result Orders of magnitude faster and more accurate than existing methods.
Clinical AI models fail to transfer between sites due to site-specific practices.
problem Clinical AI models perform poorly at new sites.
method Identify and isolate site-specific clinical practices affecting data distribution.
result A potential solution to improve model transferability.
Model learns hierarchical EHR representation for clinical outcome prediction.
problem Capturing temporal patterns in irregular clinical event sequences.
method Proposes differentiated mechanisms to model events at different time scales, learning hierarchical representations.
result Significantly improves clinical outcome prediction, achieving AUC scores of 0.94 and 0.90 for death and ICU admission respectively.
System suggests clinical concepts in real-time for faster note creation.
problem Efficiently creating structured clinical notes with minimal keystrokes.
method Contextual autocompletion using shallow neural networks.
result Reduces keystrokes by 67% in real hospital environments.
Machine learning aids in clinical prediction tasks.
problem Improving accuracy in clinical predictions.
method Introduction to machine learning concepts and algorithms, followed by practical application to clinical datasets.
result Demonstrated the application of machine learning models to clinical prediction problems.
Novel metrics improve machine learning models for ICU patient care.
problem Predicting vital sign trajectories for early detection of adverse events.
method Developed novel performance metrics aligned with clinical contexts, validated on simulated and real datasets, and optimized neural networks using these metrics.
result Neural networks trained with these metrics excel in predicting clinically significant events.
AI predicts medical specialty diagnostic choices from EHR records.
problem Predicting timely medical specialty diagnostic workups for patients.
method Ensemble of feed-forward neural networks trained on EHR data.
result Significantly higher accuracy compared to traditional checklists.
Machine learning predicts patient recruitment for clinical trials.
problem Improving patient recruitment prediction for clinical trials.
method Machine learning methods applied to historical clinical trial data.
result Reduced prediction error compared to current industry standards.
With the maturation of metabolomics science and proliferation of biobanks, clinical metabolic profiling is an increasingly opportunistic frontier for advancing translational clinical research. Automated Machine Learning (AutoML) approaches provide exciting opportunity to guide feature selection in agnostic metabolic pr…
Novel framework predicts brain biomarker trajectories with superior performance.
problem Challenges in estimating longitudinal brain biomarker trajectories due to variability, inconsistencies, and irregular measurements.
method Personalized deep kernel regression with Adaptive Shrinkage Estimation.
result Superior predictive performance compared to state-of-the-art models.
New dataset and approach improve skin cancer detection accuracy.
problem Lack of patient clinical information in automated skin cancer detection.
method Introduced a new dataset with clinical images and patient information. Combined clinical data with dermoscopy images using deep learning models.
result Combining clinical data improves skin cancer detection accuracy by around 7%.