Model predicts patient trajectories and interventions from EMR data.
arXiv research
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Convolutional neural network improves assertion detection in multi-label clinical text.
Unified model combines neural networks and dictionary learning for clinical predictions from brain data.
Modeling continuous-time physiological processes that manifest a patient's evolving clinical states is a key step in approaching many problems in healthcare. In this paper, we develop the Hidden Absorbing Semi-Markov Model (HASMM): a versatile probabilistic model that is capable of capturing the modern electronic healt…
CoI framework models clinical feature interactions, revealing temporal dependencies and enhancing transparency.
Clinical outcome prediction based on the Electronic Health Record (EHR) plays a crucial role in improving the quality of healthcare. Conventional deep sequential models fail to capture the rich temporal patterns encoded in the longand irregular clinical event sequences. We make the observation that clinical events at a…
Novel metrics improve machine learning models for ICU patient care.
Improved language model for French clinical reports achieves state-of-the-art performance in medical NLP tasks.
Clinical researchers use disease progression models to understand patient status and characterize progression patterns from longitudinal health records. One approach for disease progression modeling is to describe patient status using a small number of states that represent distinctive distributions over a set of obser…
Enhances generative model for clinical data privacy and accuracy.
AdaCare learns health status from biomarkers across multiple time scales.
Framework predicts clinical severity from rs-fMRI data using network optimization.
Automated extraction of concepts from patient clinical records is an essential facilitator of clinical research. For this reason, the 2010 i2b2/VA Natural Language Processing Challenges for Clinical Records introduced a concept extraction task aimed at identifying and classifying concepts into predefined categories (i.…
SEEDA optimizes dose allocation in clinical trials to balance efficacy and safety.
Clinical notes are a rich source of information about patient state. However, using them to predict clinical events with machine learning models is challenging. They are very high dimensional, sparse and have complex structure. Furthermore, training data is often scarce because it is expensive to obtain reliable labels…
With widespread adoption of electronic health records, there is an increased emphasis for predictive models that can effectively deal with clinical time-series data. Powered by Recurrent Neural Network (RNN) architectures with Long Short-Term Memory (LSTM) units, deep neural networks have achieved state-of-the-art resu…
SARD improves deep learning clinical prediction performance.
Study re-evaluates MIMIC-III codes, finding many are under-coded.
Method predicts biomarker trajectories with uncertainty bands for Alzheimer's disease.
Detection of interactions between treatment effects and patient descriptors in clinical trials is critical for optimizing the drug development process. The increasing volume of data accumulated in clinical trials provides a unique opportunity to discover new biomarkers and further the goal of personalized medicine, but…
Framework integrates brain connectivity data for clinical predictions.
Patients with epilepsy can manifest short, sub-clinical epileptic "bursts" in addition to full-blown clinical seizures. We believe the relationship between these two classes of events---something not previously studied quantitatively---could yield important insights into the nature and intrinsic dynamics of seizures. A…
Study investigates XAI methods in clinical gait analysis.
Unified Bayesian framework for missing data imputation and prediction in clinical time series.
Computational analysis on physiological signals would provide immense impact for enabling automated clinical analytics. However, the class imbalance issue where negative or minority class instances are rare in number impairs the robustness of the practical solution. The key idea of our approach is intelligent augmentat…
Linear Dynamical System (LDS) is an elegant mathematical framework for modeling and learning multivariate time series. However, in general, it is difficult to set the dimension of its hidden state space. A small number of hidden states may not be able to model the complexities of a time series, while a large number of …
New method targets relative risk heterogeneity in clinical trials.
The problem of missing values in multivariable time series is a key challenge in many applications such as clinical data mining. Although many imputation methods show their effectiveness in many applications, few of them are designed to accommodate clinical multivariable time series. In this work, we propose a multiple…
Clinical data for ambulatory care, which accounts for 90% of the nations healthcare spending, is characterized by relatively small sample sizes of longitudinal data, unequal spacing between visits for each patient, with unequal numbers of data points collected across patients. While deep learning has become state-of-th…
Deep chest X-ray classifiers show bias in predicting diagnoses.
SAFER improves personalized treatment recommendations for dynamic clinical contexts.
Neural SDEs model suicide risk with compact state space constraints.
A new method uses asymmetric Shapley values to assess gene importance in clinical prediction models.
Privacy-preserving inference for clinical trials using differential privacy.
Machine learning improves EEG pathology classification.
The volume of stroke lesion is the gold standard for predicting the clinical outcome of stroke patients. However, the presence of stroke lesion may cause neural disruptions to other brain regions, and these potentially damaged regions may affect the clinical outcome of stroke patients. In this paper, we introduce the t…
Joint replacement is the most common inpatient surgical treatment in the US. We investigate the clinical pathway optimization for knee replacement, which is a sequential decision process from onset to recovery. Based on episodic claims from previous cases, we view the pathway optimization as an intelligence crowdsourci…
Disease progression models are instrumental in predicting individual-level health trajectories and understanding disease dynamics. Existing models are capable of providing either accurate predictions of patients prognoses or clinically interpretable representations of disease pathophysiology, but not both. In this pape…
A new method uses Gaussian Processes for feature-based nonrigid image registration.
Model detects depression from transcribed interviews using affective language.
Clinical notes are text documents that are created by clinicians for each patient encounter. They are typically accompanied by medical codes, which describe the diagnosis and treatment. Annotating these codes is labor intensive and error prone; furthermore, the connection between the codes and the text is not annotated…
Proposes a novel imputation network for clinical time series data.
Optimum in Convex Hulls (OCH) generalizes clinical trial results to broader populations.
Information in electronic health records (EHR), such as clinical narratives, examination reports, lab measurements, demographics, and other patient encounter entries, can be transformed into appropriate data representations that can be used for downstream clinical machine learning tasks using representation learning. L…
The paper predicts diseases using both clinical and genomics data.
Personalized medicine seeks to identify the causal effect of treatment for a particular patient as opposed to a clinical population at large. Most investigators estimate such personalized treatment effects by regressing the outcome of a randomized clinical trial (RCT) on patient covariates. The realized value of the ou…
Study proposes a multimodal model for cardiovascular risk prediction using EHRs.
Improved model predicts ICU readmission and mortality with interpretable results.