The paper predicts diseases using both clinical and genomics data.
problem Clinical predictions using genomics data are not common.
method Integrated clinical and genomics datasets, machine learning, Principal Component Analysis for feature selection.
result 73% accuracy in predicting 75 disease classes.
Improved model predicts ICU readmission and mortality with interpretable results.
problem Lack of clinically interpretable predictions from deep learning models on clinical notes.
method Augmented a convolutional model with an attention mechanism for clinical note prediction.
result Attention mechanism improves prediction performance while providing interpretable results.
Machine learning aids in clinical prediction tasks.
problem Improving accuracy in clinical predictions.
method Introduction to machine learning concepts and algorithms, followed by practical application to clinical datasets.
result Demonstrated the application of machine learning models to clinical prediction problems.
Model learns hierarchical EHR representation for clinical outcome prediction.
problem Capturing temporal patterns in irregular clinical event sequences.
method Proposes differentiated mechanisms to model events at different time scales, learning hierarchical representations.
result Significantly improves clinical outcome prediction, achieving AUC scores of 0.94 and 0.90 for death and ICU admission respectively.
Machine learning predicts patient recruitment for clinical trials.
problem Improving patient recruitment prediction for clinical trials.
method Machine learning methods applied to historical clinical trial data.
result Reduced prediction error compared to current industry standards.
This study shows unstructured clinical notes can improve mortality prediction.
problem Lack of effective use of unstructured clinical notes in mortality prediction.
method Used a hierarchical architecture with convolutional and recurrent layers to predict in-hospital mortality from unprocessed clinical notes.
result Achieved higher metrics in mortality prediction compared to structured data approaches.
Late fusion of clinical notes and physiological data improves ICU mortality prediction.
problem Improving ICU mortality prediction using multimodal data.
method Late fusion of clinical notes and physiological time series data with a deep learning architecture.
result Late fusion approach provides statistically significant improvement in mortality prediction performance.
Method predicts biomarker trajectories with uncertainty bands for Alzheimer's disease.
problem Uncertainty in biomarker predictions poses risks in clinical deployment.
method Conformal prediction for randomly-timed biomarker trajectories.
result Conformal bands achieve desired coverage and are tighter than baseline.
Novel metrics improve machine learning models for ICU patient care.
problem Predicting vital sign trajectories for early detection of adverse events.
method Developed novel performance metrics aligned with clinical contexts, validated on simulated and real datasets, and optimized neural networks using these metrics.
result Neural networks trained with these metrics excel in predicting clinically significant events.
Deep learning predicts heart failure readmission from clinical notes.
problem Predicting and preventing heart failure readmission.
method Convolutional Neural Networks (CNN) trained on clinical notes.
result Deep learning models outperform traditional machine learning methods in readmission prediction.
AI predicts medical specialty diagnostic choices from EHR records.
problem Predicting timely medical specialty diagnostic workups for patients.
method Ensemble of feed-forward neural networks trained on EHR data.
result Significantly higher accuracy compared to traditional checklists.
Predictive models identify patients at risk of severe COVID-19.
problem Identifying patients at risk of severe COVID-19 to ease healthcare strain.
method Machine learning on routinely collected clinical data.
result Models predict positive SARS-CoV-2 tests, hospitalizations, and critical care with high accuracy.
The paper shows how the timing of prediction impacts model performance in healthcare.
problem The timing of prediction affects model performance in healthcare.
method The paper compares two prediction schemes: outcome-dependent and outcome-independent.
result An outcome-independent scheme outperforms an outcome-dependent scheme.
New method stabilizes deep learning models for clinical risk prediction.
problem Stability issues in deep learning models for clinical risk prediction.
method Bootstrapping-based regularisation framework embedded in deep neural networks.
result Improved prediction stability across multiple datasets.
Study improves healthcare time series imputation by considering structured missingness.
problem Structured missingness in clinical data impacts time series imputation models.
method Analysis of different masking strategies on imputation methods using PhysioNet Challenge 2012 dataset.
result Masking choices significantly affect imputation accuracy and clinical prediction.
Predict sepsis early from EHR data with aggregated clinical events.
problem Predict sepsis from clinical data in EHR with temporal interactions.
method Aggregates heterogeneous clinical events, captures temporal interactions with LSTM.
result Achieved high utility score (0.321) in PhysioNet/Computing in Cardiology Challenge 2019.
Language models improve clinical prediction models using EHR data.
problem Limited patient data for training clinical prediction models.
method Using patient representation schemes from natural language processing.
result 3.5% mean improvement in AUROC on five prediction tasks.
Enhances clinical trial predictions by quantifying uncertainty.
problem Uncertainty in medical diagnosis and drug discovery predictions.
method Selective classification integrated with Hierarchical Interaction Network (HINT).
result Significant improvement in PR-AUC, F1, ROC-AUC, and overall accuracy.
Unsupervised learning improves clinical predictions from medical time series.
problem Improving clinical decision making through unlabeled medical data.
method Evaluation of unsupervised representation learning on medical time series using sequence-to-sequence models.
result A forecasting Seq2Seq model with an attention mechanism achieves the best performance.
Natural language processing predicts AKI onset in ICU patients.
problem Early detection of AKI in ICU patients to improve outcomes.
method Clinical notes were processed to generate word and concept embeddings. Five classifiers and a deep learning model were used to predict AKI.
result The best model achieved an AUC of 0.779 for predicting AKI onset.
SARD improves deep learning clinical prediction performance.
problem Deep learning models struggle to match linear models in healthcare predictions.
method Reverse Distillation to initialize deep models, combined with contextual and temporal embeddings.
result SARD outperforms state-of-the-art methods on clinical prediction outcomes.
Causal ML predicts treatment outcomes, aiding personalized medicine.
problem Predicting individualized treatment effects for personalized medicine.
method Flexible, data-driven methods using causal inference with clinical trial and real-world data.
result Causal ML allows for estimating individualized treatment effects.
This research uses machine learning to identify Alzheimer's disease subtypes and predict progression.
problem Heterogeneity in Alzheimer's disease clinical manifestations and progression rate limit personalized care and treatment planning.
method Unsupervised and supervised machine learning approaches applied to ADNI data.
result Identification of patient subtypes and prediction of disease progression zones.
AI system predicts acute critical illness from EHRs with explainability.
problem Lack of clinical interpretability in AI predictions for acute critical illness.
method Developed an explainable AI early warning score (xAI-EWS) system.
result System provides clinicians with insights into EHR data explaining predictions.
Unified model combines neural networks and dictionary learning for clinical predictions from brain data.
problem Predicting clinical severity from brain imaging data.
method Combines neural networks with dictionary learning to model patient-specific and shared features.
result Unified model outperforms state-of-the-art methods in predicting clinical severity.
Deep RL optimizes lab test scheduling for better patient outcomes and cost savings.
problem Redundant lab tests lead to cost and patient discomfort.
method Deep reinforcement learning for optimal scheduling.
result Deep RL policy outperforms heuristic scheduling in both accuracy and cost.
Proposes clustering as a new evaluation method for clinical knowledge embedding.
problem Traditional Link Prediction evaluation protocol loses information and harms model accuracy.
method Proposes Clustering Evaluation Protocol as an alternative.
result Experimental results show the proposed protocol can potentially replace Link Prediction.
Unified Bayesian framework for missing data imputation and prediction in clinical time series.
problem High prevalence of missing values in clinical time series data.
method Unified Bayesian recurrent framework for imputation and prediction.
result Strong performance gains over state-of-the-art methods on mortality prediction tasks.
Study improves mortality prediction in hospital patients using comprehensive feature engineering.
problem Accurate prediction of all-cause in-hospital mortality in healthcare.
method Comprehensive feature engineering approach using vital signs, laboratory results, and demographic data.
result Random Forest model achieved highest performance with AUC of 0.94, significantly outperforming other models.
A new method uses asymmetric Shapley values to assess gene importance in clinical prediction models.
problem Clinical prediction models struggle with assessing the importance of high-dimensional features like genomics.
method Derive efficient algorithms to compute local and global asymmetric Shapley values for a mixed-dimensional prediction model.
result Asymmetric Shapley values provide a more suitable alternative to quantify feature importance in clinical prediction models.
Clinical notes are a rich source of information about patient state. However, using them to predict clinical events with machine learning models is challenging. They are very high dimensional, sparse and have complex structure. Furthermore, training data is often scarce because it is expensive to obtain reliable labels…
CoI framework models clinical feature interactions, revealing temporal dependencies and enhancing transparency.
problem Capturing latent, time-varying dependencies among clinical features in time-series data.
method Chain-of-Influence (CoI) framework constructs an explicit, time-unfolded graph of feature interactions.
result Achieves state-of-the-art predictive performance (AUROC of 0.960 on CKD progression and 0.950 on ICU mortality).
AdaCare learns health status from biomarkers across multiple time scales.
problem Lack of explicit extraction of historical biomarker variation and adaptability to diverse patient conditions.
method Scale-adaptive feature extraction and recalibration for interpretability.
result AdaCare achieves state-of-the-art prediction accuracy and provides interpretable results.
Model predicts patient trajectories and interventions from EMR data.
problem Forecasting patient outcomes from EMR data.
method Deep state space generative model capturing latent state dynamics.
result Model outperforms state-of-the-art methods on real EMR data.
Visual system compares and evaluates machine learning models for clinical data predictions.
problem Challenges in comparing and evaluating different machine learning models for medical predictions.
method Developed a visual analytics system to compare and evaluate multiple models' prediction criteria and consistency.
result Demonstrated the effectiveness of the visual analytics system in assisting clinicians and researchers.
Study examines impact of fairness penalties on clinical risk prediction models.
problem Widespread health disparities in machine learning-guided clinical decision-making.
method Empirical study across multiple databases, outcomes, and sensitive attributes.
result Penalizing fairness violations nearly universally degrades model performance and fairness metrics.
ConCare personalizes healthcare predictions by capturing EMR features.
problem Predicting patient outcomes from EMR data with personalization.
method Captures personal characteristics and time-aware distribution in EMR data.
result Improves healthcare prediction accuracy through personalized health context.
A clinical Meta-Dataset from TCGA for multi-task learning.
problem Clinical decision making requires considering multiple factors; current benchmarks lack consistency and variety.
method Developed a Meta-Dataset with 174 tasks from TCGA, using regression and neural networks.
result Demonstrated the feasibility of predicting multiple clinical variables from gene expression data.
Model predicts treatment initiation from clinical data using patient-clinician relations.
problem Predicting treatment initiation from clinical time series data considering patient-clinician relations.
method Graph-Augmented Time-Sensitive Model using top eigenvectors of graph Laplacian.
result Relational similarity improves prediction over baselines, e.g., 5% improvement in AUPRC.
New approach for random forests protects privacy in collaborative prediction.
problem Privacy-preserving machine learning for ensemble methods in collaborative analysis.
method Each entity learns a model locally, and predictions are computed using all locally trained models without revealing extra information.
result High efficiency and potential accuracy benefit demonstrated on real-world datasets, including EHR data.
Clinical models trained on EHRs degrade in performance over time due to data drift.
problem Model performance degradation over time in clinical settings.
method Accessed year of care for each record in MIMIC, aggregated features into clinical concepts, and tested mitigation strategies.
result State-of-the-art models show significant performance drops when tested on future data compared to historical data.
Neural model predicts survival outcomes and reveals feature relationships.
problem Predicting time-to-event outcomes and understanding feature relationships in clinical data.
method Survival and topic modeling combined in a neural network framework.
result Neural survival-supervised topic models achieve competitive accuracy with interpretability.
New method uses probabilistic independence to discover disease signatures from medical records.
problem Insufficiently precise diagnosis of clinical disease leading to treatment failures.
method Unsupervised machine learning using probabilistic independence to disentangle disease patterns.
result Inferred 2000 clinical disease signatures from medical records, improving cancer prediction.
Objectives: Electronic health records (EHRs) are only a first step in capturing and utilizing health-related data - the challenge is turning that data into useful information. Furthermore, EHRs are increasingly likely to include data relating to patient outcomes, functionality such as clinical decision support, and gen…
The medical research facilitates to acquire a diverse type of data from the same individual for particular cancer. Recent studies show that utilizing such diverse data results in more accurate predictions. The major challenge faced is how to utilize such diverse data sets in an effective way. In this paper, we introduc…
MetaPred uses meta-learning to improve clinical risk prediction from limited EHR data.
problem Clinical risk prediction from sparse patient EHR data.
method Meta-learning approach to train a meta-learner from related tasks, then fine-tune for target risk prediction.
result MetaPred achieves better performance for target risk prediction with limited data.
Study predicts antimicrobial resistance in ICU patients quickly.
problem Delayed AMR testing in ICU leads to suboptimal treatment.
method Developed predictive models using clinical and microbiological data.
result Machine learning models predict AMR with higher accuracy than naive model.
RNN models perform similarly with or without extraneous variables.
problem Impact of extraneous variables on RNN performance in clinical tasks.
method Investigated the effect of extraneous input variables on RNN predictive performance using EMR and randomly drawn variables.
result Degradations in RNN's predictive performance with extraneous variables were negligible.