We estimate treatment cost-savings from early cancer diagnosis. For breast, lung, prostate and colorectal cancers and melanoma, which account for more than 50% of new incidences projected in 2017, we combine published cancer treatment cost estimates by stage with incidence rates by stage at diagnosis. We extrapolate to…
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48 results for “Cancer Diagnosis”
With the increased affordability and availability of whole-genome sequencing, large-scale and high-throughput gene expression is widely used to characterize diseases, including cancers. However, establishing specificity in cancer diagnosis using gene expression data continues to pose challenges due to the high dimensio…
Machine learning accurately diagnoses cancer from whole genome sequencing data.
problem Accurate cancer diagnosis at all stages.
method Novel MLAC (Machine Learning Against Cancer) method using next-gen RNA sequencing.
result Perfect precision, sensitivity, and specificity achieved for most tumor types.
Novel fusion network combines polarization and radiomics features for liver cancer classification.
problem Challenges in histopathological diagnosis of HCC and ICC.
method Two-tier fusion approach: feature-level and classification-level.
result Significantly enhances classification accuracy, even at reduced resolutions.
Model learns cancer tissue images onto a low-dimensional space revealing tissue characteristics.
problem Improving cancer diagnosis through high-fidelity digital pathology.
method Deep generative model using PathologyGAN to map real images onto a latent space.
result Latent space encodes morphological characteristics and reveals distinct tissue clusters.
Late diagnosis and high costs are key factors that negatively impact the care of cancer patients worldwide. Although the availability of biological markers for the diagnosis of cancer type is increasing, costs and reliability of tests currently present a barrier to the adoption of their routine use. There is a pressing…
DDSTN improves breast cancer diagnosis by leveraging imbalanced ultrasound modalities.
problem Imbalanced ultrasound modalities in diagnosing breast cancer.
method Integrates LUPI and MMD into a deep transfer learning framework.
result Outperforms state-of-the-art algorithms in BUS-based CAD.
Signed Laplacian Deep Learning with Adversarial Augmentation for Improved Mammography Diagnosiseess.IV
Computer-aided breast cancer diagnosis in mammography is limited by inadequate data and the similarity between benign and cancerous masses. To address this, we propose a signed graph regularized deep neural network with adversarial augmentation, named \textsc{DiagNet}. Firstly, we use adversarial learning to generate p…
Breast Cancer Histopathology Image Classification and Localization using Multiple Instance Learningcs.CV
A-MIL improves histopathology image classification and localization.
problem Improving diagnosis of breast cancer through better interpretation of histopathology images.
method Frame image classification as multiple instance learning, use attention-based learning for localization.
result A-MIL achieves better localization without compromising classification accuracy.
High predictive performance and ease of use and interpretability are important requirements for the applicability of a computer-aided diagnosis (CAD) to human reading studies. We propose a CAD system specifically designed to be more comprehensible to the radiologist reviewing screening breast MRI studies. Multiparametr…
Study compares single vs ensemble feature selection for cancer diagnosis.
problem Identifying relevant variables for cancer diagnosis and prognosis.
method Comparison of single feature selection algorithms and ensemble of diverse algorithms.
result Ensemble approach did not improve predictive performance over individual algorithms.
In this paper, we analyze the Wisconsin Diagnostic Breast Cancer Data using Machine Learning classification techniques, such as the SVM, Bayesian Logistic Regression (Variational Approximation), and K-Nearest-Neighbors. We describe each model, and compare their performance through different measures. We conclude that S…
Breast cancer is the most frequently reported cancer type among the women around the globe and beyond that it has the second highest female fatality rate among all cancer types. Despite all the progresses made in prevention and early intervention, early prognosis and survival prediction rates are still unsatisfactory. …
A two-layer neural network model that systematically includes correlations among input variables to arbitrary order and is designed to implement Bayes inference has been adapted to classify breast cancer tumors as malignant or benign, assigning a probability for either outcome. The inputs to the network represent measu…
Study identifies biomarkers for lung cancer in female non-smokers.
problem Identifying prognostic biomarkers for stage III NSCLC in non-smoking females.
method Gene expression profiling and XGBoost machine learning algorithm.
result Top biomarkers validated in literature, with AUC score of 0.835.
A novel deep learning architecture (XmasNet) based on convolutional neural networks was developed for the classification of prostate cancer lesions, using the 3D multiparametric MRI data provided by the PROSTATEx challenge. End-to-end training was performed for XmasNet, with data augmentation done through 3D rotation a…
With an aging and growing population, the number of women requiring either screening or symptomatic mammograms is increasing. To reduce the number of mammograms that need to be read by a radiologist while keeping the diagnostic accuracy the same or better than current clinical practice, we develop Man and Machine Mammo…
A DenseNet model classifies metastatic cancer in medical images.
problem Classifying metastatic cancer in medical images efficiently and accurately.
method Proposes a DenseNet-based model for metastatic cancer classification on medical images.
result The proposed model outperformed other classical methods like Resnet34, Vgg19.
Scalable Reinforcement-Learning-Based Neural Architecture Search for Cancer Deep Learning Researchcs.LG
Cancer is a complex disease, the understanding and treatment of which are being aided through increases in the volume of collected data and in the scale of deployed computing power. Consequently, there is a growing need for the development of data-driven and, in particular, deep learning methods for various tasks such …
Automatization of the diagnosis of any kind of disease is of great importance and it's gaining speed as more and more deep learning solutions are applied to different problems. One of such computer aided systems could be a decision support too able to accurately differentiate between different types of breast cancer hi…
Lung cancer is the leading cause of cancer-related death worldwide. Early diagnosis of pulmonary nodules in Computed Tomography (CT) chest scans provides an opportunity for designing effective treatment and making financial and care plans. In this paper, we consider the problem of diagnostic classification between beni…
Two new feature selection methods improve breast cancer diagnosis accuracy.
problem Improving breast cancer diagnosis accuracy and reducing dataset dimensions.
method Imperialist Competitive Algorithm (ICA) and Bat Algorithm (BA) integrated with ML algorithms.
result BA-based feature selection method outperforms other methods with 99.12% accuracy.
New method uses probabilistic independence to discover disease signatures from medical records.
problem Insufficiently precise diagnosis of clinical disease leading to treatment failures.
method Unsupervised machine learning using probabilistic independence to disentangle disease patterns.
result Inferred 2000 clinical disease signatures from medical records, improving cancer prediction.
Histopathological images of tumors contain abundant information about how tumors grow and how they interact with their micro-environment. Better understanding of tissue phenotypes in these images could reveal novel determinants of pathological processes underlying cancer, and in turn improve diagnosis and treatment opt…
Identification of Cancer -- Mesothelioma Disease Using Logistic Regression and Association Rulecs.CY
Malignant Pleural Mesothelioma (MPM) or malignant mesothelioma (MM) is an atypical, aggressive tumor that matures into cancer in the pleura, a stratum of tissue bordering the lungs. Diagnosis of MPM is difficult and it accounts for about seventy-five percent of all mesothelioma diagnosed yearly in the United States of …
Objectives: Most cancer data sources lack information on metastatic recurrence. Electronic medical records (EMRs) and population-based cancer registries contain complementary information on cancer treatment and outcomes, yet are rarely used synergistically. To enable detection of metastatic breast cancer (MBC), we appl…
Capsule network improves polyp diagnosis accuracy.
problem Low accuracy of optical biopsy methods for polyps.
method D-Caps architecture with CAP method.
result 43% improvement over previous state-of-the-art.
Discovering oral cavity cancer (OCC) at an early stage is an effective way to increase patient survival rate. However, current initial screening process is done manually and is expensive for the average individual, especially in developing countries worldwide. This problem is further compounded due to the lack of speci…
Mammography is often used as the most common laboratory method for the detection of breast cancer, yet associated with the high cost and many side effects. Machine learning prediction as an alternative method has shown promising results. This paper presents a method based on a multilayer fuzzy expert system for the det…
Medical image registration is one of the key processing steps for biomedical image analysis such as cancer diagnosis. Recently, deep learning based supervised and unsupervised image registration methods have been extensively studied due to its excellent performance in spite of ultra-fast computational time compared to …
The widespread digitization of patient data via electronic health records (EHRs) has created an unprecedented opportunity to use machine learning algorithms to better predict disease risk at the patient level. Although predictive models have previously been constructed for a few important diseases, such as breast cance…
Over 150,000 new people in the United States are diagnosed with colorectal cancer each year. Nearly a third die from it (American Cancer Society). The only approved noninvasive diagnosis tools currently involve fecal blood count tests (FOBTs) or stool DNA tests. Fecal blood count tests take only five minutes and are av…
Automated Prostate Cancer Diagnosis Based on Gleason Grading Using Convolutional Neural Networkeess.IV
CNN-based prostate cancer grading improves accuracy and efficiency.
problem Manual Gleason grading by pathologists is time-consuming and prone to errors.
method Patch-Based Image Reconstruction (PBIR), Distribution Correction (DC), Quadratic Weighted Mean Square Error (QWMSE).
result Achieved superior expert-level performance (0.8885 quadratic-weighted kappa coefficient).
One of the challenges of using machine learning techniques with medical data is the frequent dearth of source image data on which to train. A representative example is automated lung cancer diagnosis, where nodule images need to be classified as suspicious or benign. In this work we propose an automatic synthetic lung …
Celiac Disease (CD) is a chronic autoimmune disease that affects the small intestine in genetically predisposed children and adults. Gluten exposure triggers an inflammatory cascade which leads to compromised intestinal barrier function. If this enteropathy is unrecognized, this can lead to anemia, decreased bone densi…
Proposes ConRad model for lung cancer classification using radiomics and interpretable machine learning.
problem Lack of interpretability in deep neural networks for cancer diagnosis.
method Integration of radiomics and DNN-predicted biomarkers in interpretable classifiers (ConRad).
result ConRad models outperform CNNs in five-fold cross-validation.
Intraductal papillary mucinous neoplasm (IPMN) is a precursor to pancreatic ductal adenocarcinoma. While over half of patients are diagnosed with pancreatic cancer at a distant stage, patients who are diagnosed early enjoy a much higher 5-year survival rate of compared to in the former; hence, early diagno…
Weakly supervised instance labeling using only image-level labels, in lieu of expensive fine-grained pixel annotations, is crucial in several applications including medical image analysis. In contrast to conventional instance segmentation scenarios in computer vision, the problems that we consider are characterized by …
We present an extension of sparse Canonical Correlation Analysis (CCA) designed for finding multiple-to-multiple linear correlations within a single set of variables. Unlike CCA, which finds correlations between two sets of data where the rows are matched exactly but the columns represent separate sets of variables, th…
A Pathology report is arguably one of the most important documents in medicine containing interpretive information about the visual findings from the patient's biopsy sample. Each pathology report has a retention period of up to 20 years after the treatment of a patient. Cancer registries process and encode high volume…
The paper tackles Neyman-Pearson classification control issues.
problem Neyman-Pearson classification's control constraint is hard to satisfy in finite samples.
method Developed refined learning procedures under two accuracy control strategies.
result Proposed methods achieve desired control levels in finite samples.
Motivation : Molecular signatures for diagnosis or prognosis estimated from large-scale gene expression data often lack robustness and stability, rendering their biological interpretation challenging. Increasing the signature's interpretability and stability across perturbations of a given dataset and, if possible, acr…
Model predicts anti-cancer drug responses using gene and molecular data.
problem Expensive and time-consuming cancer drug discovery and tailoring.
method Uses variational autoencoders and multi-layer perceptrons to encode gene expression and drug data.
result High average of 0.83 and 0.845 in predicting drug responses for breast and pan-cancer cell lines, respectively.
We present a novel method for extracting cancer signatures by applying statistical risk models (http://ssrn.com/abstract=2732453) from quantitative finance to cancer genome data. Using 1389 whole genome sequenced samples from 14 cancers, we identify an "overall" mode of somatic mutational noise. We give a prescription …
We explore how Deep Learning (DL) can be utilized to predict prognosis of acute myeloid leukemia (AML). Out of TCGA (The Cancer Genome Atlas) database, 94 AML cases are used in this study. Input data include age, 10 common cytogenetic and 23 most common mutation results; output is the prognosis (diagnosis to death, DTD…
Cardiotoxicity related to cancer therapies has become a serious issue, diminishing cancer treatment outcomes and quality of life. Early detection of cancer patients at risk for cardiotoxicity before cardiotoxic treatments and providing preventive measures are potential solutions to improve cancer patients's quality of …
Lung cancer is one of the death threatening diseases among human beings. Early and accurate detection of lung cancer can increase the survival rate from lung cancer. Computed Tomography (CT) images are commonly used for detecting the lung cancer.Using a data set of thousands of high-resolution lung scans collected from…
Mammographic breast density, a parameter used to describe the proportion of breast tissue fibrosis, is widely adopted as an evaluation characteristic of the likelihood of breast cancer incidence. In this study, we present a radiomics approach based on residual learning for the classification of mammographic breast dens…