New method improves support estimation for unknown distributions.
problem Estimating the support size of an unknown distribution.
method Regularized Weighted Chebyshev Approximations, joint optimization of bias and variance, linear programming.
result Significant improvements in worst-case risk for synthetic data and accurate bacterial genus estimation for microbiome data.
Deep learning identifies 30 common bacterial pathogens from Raman spectra.
problem Rapid and accurate identification of pathogenic bacteria.
method State-of-the-art deep learning applied to large Raman spectroscopy dataset.
result 99.0% accuracy in identifying 30 common bacterial pathogens.
Paper uses machine learning to identify key pathways for c-di-GMP in bacterial genomes.
problem Understanding pathways essential for c-di-GMP in bacterial cellulose production.
method Applied Lasso and Random Forests for feature selection and modeling gene count data.
result Bacterial chemotaxis is identified as the most essential pathway for c-di-GMP encoding domains.
Deep learning automates bacterial image classification.
problem Manual bacterial classification is time-consuming and error-prone.
method ResNet-50 pre-trained CNN architecture with transfer learning.
result Average classification accuracy of 99.2%.
Machine learning identifies key metabolic control circuits in bacterial pathways.
problem Identifying regulated metabolic pathways in bacteria.
method Machine learning approach analyzing multi-omics data.
result Identification of E. coli Glycolysis regulatory circuits.
Logistic regression with wavelets achieves bacterial infection detection accuracy.
problem Interpreting complex biomedical signal models for high-stakes decisions.
method Wavelet features and knockoff variables for feature selection.
result Logistic regression outperforms neural networks in bacterial infection detection.
Study uses machine learning to optimize antibiotic therapy for MRSA skin infections.
problem Optimizing antibiotic choice for MRSA skin infections due to reduced treatment options and side effects.
method Propensity score matching, machine learning models (SVM, RF, LASSO), counterfactual analysis.
result RF model shows stronger treatment heterogeneity and potential for therapy change.
Bayesian model fuses diverse microbiome data types.
problem Challenges in fusing different types of microbiome data.
method Flexible multinomial-Gaussian generative model with variational EM algorithm.
result Inferred latent variables provide common dimensionality reduction and predictive posterior distribution.
Machine learning model diagnoses COVID-19 from routine blood tests.
problem Difficulty in diagnosing COVID-19 due to inconsistent blood parameter changes.
method Constructed a machine learning model using 5,333 patients with various infections and 160 COVID-19-positive patients.
result Cross-validated AUC of 0.97, sensitivity of 81.9%, specificity of 97.9%.
We consider the problem of joint modelling of metabolic signals and gene expression in systems biology applications. We propose an approach based on input-output factorial hidden Markov models and propose a structured variational inference approach to infer the structure and states of the model. We start from the class…
Antimicrobial resistance is an important public health concern that has implications in the practice of medicine worldwide. Accurately predicting resistance phenotypes from genome sequences shows great promise in promoting better use of antimicrobial agents, by determining which antibiotics are likely to be effective i…
Increasingly complex generative models are being used across disciplines as they allow for realistic characterization of data, but a common difficulty with them is the prohibitively large computational cost to evaluate the likelihood function and thus to perform likelihood-based statistical inference. A likelihood-free…
Improved likelihood-free inference for high-dimensional models.
problem Challenges in likelihood-free inference for high-dimensional parameter spaces.
method Bayesian optimization-based approach with misspecification-robust characterisation.
result Efficient inference in 100-dimensional space with real data application.
Coregulation of the expression of groups of genes has been extensively demonstrated empirically in bacterial and eukaryotic systems. Such coregulation can arise through the use of shared regulatory motifs, which allow the coordinated expression of modules (and module groups) of functionally related genes across the gen…
Many complex ecosystems, such as those formed by multiple microbial taxa, involve intricate interactions amongst various sub-communities. The most basic relationships are frequently modeled as co-occurrence networks in which the nodes represent the various players in the community and the weighted edges encode levels o…
New knots found with Seifert genus not matching minimal genus Seifert surfaces.
problem Discrepancy between Seifert genus and minimal genus Seifert surfaces.
method Constructed knots with specific genus and handle numbers to demonstrate the discrepancy.
result Found knots where Seifert genus is not realized by minimal genus Seifert surfaces.
Construct divide knots with specific genus properties.
problem Understanding the difference between smooth and topological four-genus for knots.
method Construct divide knots with controlled smooth and topological four-genus ratios.
result For strongly quasipositive fibred knots, the ratio between smooth and topological four-genus can be made arbitrarily close to zero.
The concordance genus of a knot K is the minimum Seifert genus of all knots smoothly concordant to K. Concordance genus is bounded below by the 4-ball genus and above by the Seifert genus. We give a lower bound for the concordance genus of K coming from the knot Floer complex of K. As an application, we prove that ther…
The paper generalizes the T-genus to characterize slice knots and slice genus.
problem Characterizing slice knots and slice genus using the T-genus. method Generalizing the T-genus to provide a 3-dimensional characterization of the slice genus. result The difference between the T-genus and the slice genus can be arbitrarily large. Characterizes the Z-genus of boundary links using Blanchfield forms.
problem Determining the Z-genus of boundary links.
method Characterization using Blanchfield forms.
result Variant of shake genus equals Z-genus of knot.
The concordance genus of a knot is the least genus of any knot in its concordance class. Although difficult to compute, it is a useful invariant that highlights the distinction between the three-genus and four-genus. In this paper we define and discuss the stable concordance genus of a knot, which describes the behavio…
Study shows four-genus ratio of two-bridge knots decreases as knots get more complex.
problem Understanding the relationship between smooth four-genus and Seifert genus in two-bridge knots.
method Analytical proof focusing on two-bridge knots and their crossing numbers.
result The expected value of the ratio between smooth four-genus and Seifert genus tends to zero as the crossing number increases.
Classifies 3-braid knots with maximal 4-genus using McCoy's method.
problem Classifying 3-braid knots with maximal 4-genus.
method McCoy's twisting method and Xu normal form.
result Upper bounds for the topological 4-genus of 3-braid knots.
Study shows non-equivariant and equivariant non-orientable 4-genus of periodic knots can differ.
problem Exploring differences in non-orientable 4-genus for periodic knots.
method Analyzed p-periodic knots, showing differences in equivariant and non-equivariant non-orientable 4-genus.
result Differences exist in non-equivariant and equivariant non-orientable 4-genus for periodic knots.
Study Khovanov homology of Turaev genus one links, finding a trivial summand.
problem Analyzing Khovanov homology of Turaev genus one links.
method Examined Khovanov homology in specific polynomial gradings.
result Found a trivial summand in Khovanov homology of Turaev genus one links.
Contact connected sums do not increase support genus.
problem Understanding how support genus changes under contact connected sums.
method Analyzing the support genus of contact connected sums of 3-manifolds.
result The support genus of contact connected sums is at most the maximum of the summands' support genera.
The concordance genus of a knot is the least genus of any knot in its concordance class. It is bounded above by the genus of the knot, and bounded below by the slice genus, two well-studied invariants. In this paper we consider the concordance genus of 11--crossing prime knots. This analysis resolves the concordance ge…
This article is about the graph genus of certain well studied graphs in surface theory: the curve, pants and flip graphs. We study both the genus of these graphs and the genus of their quotients by the mapping class group. The full graphs, except for in some low complexity cases, all have infinite genus. The curve grap…
Classifies knot traces with specific trisection genus limits.
problem Classifying knot traces with specific trisection genus limits.
method Classifying knot traces with specific trisection genus limits.
result Infinitely many knots have traces with trisection genus 3 and 4, and arbitrarily large trisection genus.
The paper proves a conjecture about satellite knots and their slice genus.
problem The topological slice genus of satellite knots and its bounds.
method Establishes the conjecture for a variant of the topological slice genus, the Z-slice genus.
result The topological slice genus of a satellite knot is bounded above by the sum of the slice genera of the knot and the pattern.
Classifies Teichmüller curves in genus three from genus two.
problem Classifying Teichmüller curves in genus three from genus two.
method Action on homology modulo two of affine groups of translation surfaces.
result Classification of orbits of square-tiled surfaces.
The paper proves trisection genus of Akbulut cork and constructs many corks with trisection genus 3.
problem Determining the trisection genus of contractible 4-manifolds and exotic pairs.
method Proved trisection genus of Akbulut cork and constructed corks with trisection genus 3.
result First examples of contractible 4-manifolds with determined trisection genus except for 4-ball.
New expanders for mean curvature flow contradict genus-reduction conjecture.
problem Contradicting Ilmanen's genus-reduction conjecture for mean curvature flow.
method Construct new expanders asymptotic to cones arising from shrinkers.
result Existence of expanders of arbitrarily large genus.
Lower bounds on rational slice genus using Heegaard Floer invariants.
problem Measuring complexity of homology classes in 4-manifolds.
method Introducing rational slice genus, bounding Heegaard Floer τ invariants, using satellite links and closed braids.
result Lower bounds on rational slice genus in terms of Heegaard Floer τ invariants.
Deep learning ensembles improve COVID-19 detection from chest X-rays.
problem Detecting COVID-19 from chest X-rays using machine learning.
method Custom CNN and ImageNet models, transfer learning, iterative pruning, ensemble learning.
result 99.01% accuracy in detecting COVID-19 from chest X-rays.
Study shows systole behavior changes significantly for large genus hyperbolic surfaces.
problem Understanding systole behavior in large genus hyperbolic surfaces.
method Analysis of random surfaces with respect to Weil-Petersson volume.
result Expected value of separating systole behaves like 2logg for large genus. Survey of minimal genus problem progress.
problem Finding the smallest genus surface in 3-manifolds.
method Survey and review of existing research.
result Summarizes recent advancements in the minimal genus problem.
Algorithm calculates genus of embedded graphs on surfaces.
problem Finding minimal and maximal genus for graph embeddings.
method Constructing special branched coverings of the 2-sphere.
result Algorithm calculates orientable genus and maximal genus of graphs.
In this paper, we develop a lower bound for the double slice genus of a knot using Casson-Gordon invariants. As an application, we show that the double slice genus can be arbitrarily larger than twice the slice genus. As an analogue to the double slice genus, we also define the superslice genus of a knot, and give both…
For each g > 2 and h > 1, we explicitly construct (1) fiber sum indecomposable relatively minimal genus g Lefschetz fibrations over genus h surfaces whose monodromies lie in the Torelli group, (2) fiber sum indecomposable genus g surface bundles over genus h surfaces whose monodromies are in the Torelli group (provided…
The paper explores the genus of surfaces in complex projective spaces and improves minimal genus bounds.
problem Investigating the genus of surfaces in complex projective spaces.
method Analyzing knots and torus knots in CP2 and CP2#CP2. result The CP2-genus of knots is unbounded, unlike its topological counterpart. The paper uses twisting operations to bound knot genus.
problem Bounding the topological slice genus of knots.
method Develops null-homologous twisting operations to study algebraic genus.
result New upper bounds on algebraic genera of torus and satellite knots.
Shows large unknotting number for simple knots.
problem Finding minimum crossing changes for unknotting.
method Positive-to-negative crossing changes without increasing genus.
result Genus non-increasing totally positive unknotting number can be large.
A new method shows open Riemann surfaces have finite genus.
problem Determining the genus of open Riemann surfaces.
method Introducing a quotient space of forms to determine finite genus.
result Open Riemann surfaces have finite genus and can be embedded in a compact surface.
We introduce a new link invariant called the algebraic genus, which gives an upper bound for the topological slice genus of links. In fact, the algebraic genus is an upper bound for another version of the slice genus proposed here: the minimal genus of a surface in the four-ball whose complement has infinite cyclic fun…
The paper calculates genus bounds for multibranched surfaces.
problem Finding genus bounds for multibranched surfaces.
method Using the first Betti number and boundary genus, the paper provides lower bounds for maximum and minimum genus.
result The maximum and minimum genus of GimesS1 equals twice that of G. Correspondence found between Askey-Wilson polynomials and genus-two handlebody skein module.
problem Understanding the genus-two handlebody skein module.
method Using q-difference operators for the genus-two skein algebra.
result Correspondence between reduced Askey-Wilson polynomials and genus-two handlebody skein module.
Study cohomology of mapping class groups for big genus surfaces.
problem Characterize the first cohomology of pure mapping class groups for genus one and zero surfaces.
method Analyzes the first integral cohomology of pure mapping class groups for infinite type genus one surfaces and genus zero surfaces.
result For genus one surfaces, the first integral cohomology is trivial. For genus zero surfaces, there is an uncountable family of non-trivial homomorphisms to Z.