In recent years, the number of papers on Alzheimer's disease classification has increased dramatically, generating interesting methodological ideas on the use machine learning and feature extraction methods. However, practical impact is much more limited and, eventually, one could not tell which of these approaches are…
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48 results for “ADNI”
Paper revisits graph-CNNs using Laplace-Beltrami spectral filters and polynomials.
problem Improving spectral graph convolutional neural networks (graph-CNNs).
method Developed Laplace-Beltrami CNN (LB-CNN) by replacing graph Laplacian with LB operator and approximating spectral filters using Chebyshev, Laguerre, and Hermite polynomials.
result Classification accuracy of LB-CNN is not dependent on the type of polynomials or operators.
ADCB: An Alzheimer's disease benchmark for evaluating observational estimators of causal effectscs.LG
Proposes a new Alzheimer's disease simulator for causal effect estimation.
problem Lack of suitable benchmarks for evaluating causal effect estimators in real-world healthcare data.
method Developed a simulator of Alzheimer's disease using ADNI dataset, incorporating various parameters to model complexities.
result Compared estimators of average and conditional treatment effects using the new simulator.
A test for neural networks identifies genetic associations.
problem Testing complex associations in neural networks.
method Sieve quasi-likelihood ratio test for neural networks with one hidden layer.
result The test statistic has an asymptotic chi-squared distribution.
A new kernel measures brain network similarities, improving disease classification.
problem Lack of edge weight information in existing graph kernels for brain connectivity networks.
method Ordinal pattern kernel for weighted brain connectivity networks.
result The ordinal pattern kernel achieves better classification performance than state-of-the-art graph kernels.
Bayesian meta-learning predicts Alzheimer's disease progression.
problem Predicting individual Alzheimer's disease progression from limited data.
method Bayesian meta-learning approach that dynamically predicts disease score distributions.
result Bayesian meta-learner outperforms single-task models and deterministic meta-learners, especially for long-term predictions.
Exploiting the wealth of imaging and non-imaging information for disease prediction tasks requires models capable of representing, at the same time, individual features as well as data associations between subjects from potentially large populations. Graphs provide a natural framework for such tasks, yet previous graph…
Motivation: Recent advances in technology for brain imaging and high-throughput genotyping have motivated studies examining the influence of genetic variation on brain structure. Wang et al. (Bioinformatics, 2012) have developed an approach for the analysis of imaging genomic studies using penalized multi-task regressi…
Pattern recognition methods using neuroimaging data for the diagnosis of Alzheimer's disease have been the subject of extensive research in recent years. In this paper, we use deep learning methods, and in particular sparse autoencoders and 3D convolutional neural networks, to build an algorithm that can predict the di…
Paper proposes machine learning model for early Alzheimer's diagnosis.
problem Early and accurate diagnosis of Alzheimer's Disease.
method Machine learning models, demographic, biomarker, and cognitive test data.
result 90% accuracy and 87% accuracy in predicting Alzheimer's development.
Fed-MIWAE improves federated learning by imputing missing data.
problem Handling missing data in federated learning models.
method Federated version of MIWAE, a deep latent variable model for missing data imputation.
result Fed-MIWAE achieves imputation accuracy comparable to centralized methods in federated scenarios.
Graphs are widely used as a natural framework that captures interactions between individual elements represented as nodes in a graph. In medical applications, specifically, nodes can represent individuals within a potentially large population (patients or healthy controls) accompanied by a set of features, while the gr…
Here we present DIVE: Data-driven Inference of Vertexwise Evolution. DIVE is an image-based disease progression model with single-vertex resolution, designed to reconstruct long-term patterns of brain pathology from short-term longitudinal data sets. DIVE clusters vertex-wise biomarker measurements on the cortical surf…
A large number of papers have introduced novel machine learning and feature extraction methods for automatic classification of AD. However, they are difficult to reproduce because key components of the validation are often not readily available. These components include selected participants and input data, image prepr…
Alzheimer's Disease (AD) is characterized by a cascade of biomarkers becoming abnormal, the pathophysiology of which is very complex and largely unknown. Event-based modeling (EBM) is a data-driven technique to estimate the sequence in which biomarkers for a disease become abnormal based on cross-sectional data. It can…
Deep learning models brain deformations based on atrophy and growth data.
problem Simulating brain deformations due to atrophy and growth.
method Differentiable biomechanical model using deep learning.
result Trained model can rapidly simulate new brain deformations with minimal residuals.
On the design of convolutional neural networks for automatic detection of Alzheimer's diseaseeess.IV
Early detection is a crucial goal in the study of Alzheimer's Disease (AD). In this work, we describe several techniques to boost the performance of 3D deep convolutional neural networks (CNNs) trained to detect AD using structural brain MRI scans. Specifically, we provide evidence that (1) instance normalization outpe…
New method predicts Alzheimer's risk with individual uncertainty estimates.
problem Predicting conversion from mild cognitive impairment to Alzheimer's disease.
method Persistent homology of clinical trajectories combined with stacking ensemble.
result Pipeline achieves high accuracy and individual-level uncertainty quantification.
A new framework detects statistical significance of deep learning in neuroimaging studies.
problem Lack of statistical significance testing in deep learning neuroimaging.
method Non-parametric framework using autoencoders and SVM, with random-effects inference and cross-validation.
result CV and RUB methods offer acceptable false positive rates and statistical power, but low generalization ability.
Transformers improve Alzheimer's disease progression prediction by accounting for irregular biomarker histories.
problem Difficult prediction of medium-horizon Alzheimer's disease progression due to tied clinical scores and irregular biomarker observations.
method Developed a residual gap-aware transformer that combines statistical reference with transformer-based residual learning.
result The proposed model reduces mean error and improves prediction-observation correlation compared to baseline models.
Arguably, unsupervised learning plays a crucial role in the majority of algorithms for processing brain imaging. A recently introduced unsupervised approach Deep InfoMax (DIM) is a promising tool for exploring brain structure in a flexible non-linear way. In this paper, we investigate the use of variants of DIM in a se…
QC-SPHARM detects Alzheimer's Disease early using hippocampal surface geometry.
problem Early detection of Alzheimer's Disease (AD) using hippocampal surface geometry.
method Spherical harmonics registration, conformality and curvature distortions quantification, t-test feature selection, SVM classification.
result 85.2% testing accuracy on ADNI data, 81.2% on aMCI progression data.
Automated methods for Alzheimer's disease (AD) classification have the potential for great clinical benefits and may provide insight for combating the disease. Machine learning, and more specifically deep neural networks, have been shown to have great efficacy in this domain. These algorithms often use neurological ima…
At this moment, databanks worldwide contain brain images of previously unimaginable numbers. Combined with developments in data science, these massive data provide the potential to better understand the genetic underpinnings of brain diseases. However, different datasets, which are stored at different institutions, can…
We developed a convolution neural network (CNN) on semi-regular triangulated meshes whose vertices have 6 neighbours. The key blocks of the proposed CNN, including convolution and down-sampling, are directly defined in a vertex domain. By exploiting the ordering property of semi-regular meshes, the convolution is defin…
Enhanced Survival Treesstat.ME
Enhanced survival trees improve computational efficiency and inference.
problem Censored failure time data and variable selection bias.
method Improved splitting procedure, intersected validation, fused regularization, and bootstrap-based bias correction.
result Valid confidence intervals for median survival times.
Early diagnosis, playing an important role in preventing progress and treating the Alzheimer\{'}s disease (AD), is based on classification of features extracted from brain images. The features have to accurately capture main AD-related variations of anatomical brain structures, such as, e.g., ventricles size, hippocamp…
GLasso: Regularized Multi-task Graphical Lasso for Joint Estimation of eQTL Mapping and Gene Networkstat.ML
A new method for joint eQTL mapping and gene network estimation.
problem Discovering SNP-gene relationships and gene-gene relationships in gene expression regulation.
method L1-2 regularized multi-task graphical lasso (L1-2 GLasso).
result Competitive performance on capturing true sparse structures of eQTL mapping and gene network.
Early diagnosis, playing an important role in preventing progress and treating the Alzheimer's disease (AD), is based on classification of features extracted from brain images. The features have to accurately capture main AD-related variations of anatomical brain structures, such as, e.g., ventricles size, hippocampus …
New method handles missing data in multimodal brain imaging.
problem Missing data in multimodal brain imaging.
method Full Information Linked ICA (FI-LICA) algorithm.
result FI-LICA outperforms current practices in classification and prediction.
Imaging-based early diagnosis of Alzheimer Disease (AD) has become an effective approach, especially by using nuclear medicine imaging techniques such as Positron Emission Topography (PET). In various literature it has been found that PET images can be better modeled as signals (e.g. uptake of florbetapir) defined on a…
Alzheimer's disease (AD) is a degenerative brain disease impairing a person's ability to perform day to day activities. The clinical manifestations of Alzheimer's disease are characterized by heterogeneity in age, disease span, progression rate, impairment of memory and cognitive abilities. Due to these variabilities, …
In this paper, we propose a framework for automatic classification of patients from multimodal genetic and brain imaging data by optimally combining them. Additive models with unadapted penalties (such as the classical group lasso penalty or -multiple kernel learning) treat all modalities in the same manner and ca…
Binary classification is a common statistical learning problem in which a model is estimated on a set of covariates for some outcome indicating the membership of one of two classes. In the literature, there exists a distinction between hard and soft classification. In soft classification, the conditional class probabil…
For precision medicine and personalized treatment, we need to identify predictive markers of disease. We focus on Alzheimer's disease (AD), where magnetic resonance imaging scans provide information about the disease status. By combining imaging with genome sequencing, we aim at identifying rare genetic markers associa…
ProJIVE integrates multiple data types to explain joint and individual variation.
problem Integrating multiple types of data on the same subjects.
method Probabilistic EM algorithm for JIVE framework.
result ProJIVE learns biologically meaningful courses of variation and improves accuracy.
Hierarchical-CPI improves variable importance measurement for medical data.
problem Limited interpretability of complex medical models.
method Hierarchical-CPI measures conditional variable importance with statistical control, handling correlated data.
result Hierarchical-CPI outperforms existing methods in medical datasets.
Second generation sequencing technologies are being increasingly used for genetic association studies, where the main research interest is to identify sets of genetic variants that contribute to various phenotype. The phenotype can be univariate disease status, multivariate responses and even high-dimensional outcomes.…
ICAM: Interpretable Classification via Disentangled Representations and Feature Attribution Mappingcs.LG
ICAM creates interpretable feature attribution maps for brain images.
problem Challenges in predicting class relevance from brain images due to heterogeneity and background variation.
method A VAE-GAN framework for disentangling class relevance from background features.
result FA maps generated by ICAM outperform baseline methods and support phenotype variation exploration.
AdapDISCOM tackles high-dimensional multimodal data with missingness and errors, improving prediction and biomarker selection.
problem High-dimensional multimodal data with block-wise missingness and measurement errors.
method AdapDISCOM introduces modality-specific weighting schemes to address heterogeneity and error magnitudes.
result AdapDISCOM consistently outperforms existing methods under heterogeneous contamination and heavy-tailed distributions.
THS-GAN uses tensorizing and high-order pooling for AD diagnosis.
problem Early diagnosis of Alzheimer's Disease (AD) using MRI images.
method Tensorizing a three-player cooperative game framework with high-order pooling for MRI images.
result THS-GAN achieves superior performance in AD diagnosis compared to existing methods.
Alzheimer's disease (AD) is the most common neurodegenerative disease in older people. Despite considerable efforts to find a cure for AD, there is a 99.6% failure rate of clinical trials for AD drugs, likely because AD patients cannot easily be identified at early stages. This project investigated machine learning app…
Deep model predicts shapes of curves with multiple covariates.
problem Predicting shapes of planar curves with various covariates.
method Deep learning model using complex-valued functions, conditional covariance smoother with modality-specific encoders.
result Model accurately predicts shapes of curves with multimodal covariates.
Proposes a VAE for HDLSS data augmentation.
problem Data augmentation in HDLSS settings with small sample sizes.
method Geometry-based variational autoencoder with latent space modeling.
result Significant improvement in classification metrics (e.g., balanced accuracy from 66.3% to 74.3%).
The use of machine-learning in neuroimaging offers new perspectives in early diagnosis and prognosis of brain diseases. Although such multivariate methods can capture complex relationships in the data, traditional approaches provide irregular (l2 penalty) or scattered (l1 penalty) predictive pattern with a very limited…
SHAP clustering explains model predictions by grouping similar feature contributions.
problem Lack of explainability in black-box models.
method SHAP values for feature contributions, supervised clustering of SHAP values.
result Insight into pathways leading to similar predictions.
DiffeoCFM efficiently generates realistic brain connectivity matrices using pullback metrics.
problem Generating realistic brain connectivity matrices for population heterogeneity analysis.
method Conditional flow matching on matrix manifolds via pullback metrics induced by global diffeomorphisms.
result DiffeoCFM achieves state-of-the-art performance on large-scale fMRI and EEG datasets.
We introduce a novel personalized Gaussian Process Experts (pGPE) model for predicting per-subject ADAS-Cog13 cognitive scores -- a significant predictor of Alzheimer's Disease (AD) in the cognitive domain -- over the future 6, 12, 18, and 24 months. We start by training a population-level model using multi-modal data …